妊娠期高血压疾病患者肾脏损伤指标探讨.docVIP

妊娠期高血压疾病患者肾脏损伤指标探讨 　　[摘要]目的探讨妊娠期高血压疾病患者肾脏损伤的早期诊断方法。方法 采用全自动生化分析仪,分别对72例妊娠期高血压疾病患者(研究组)及53例正常孕妇(对照组)检测尿微量白蛋白(umA),β2-微球蛋白(uβ2-MG),N-乙酰-β-D苷酶(NAG),胱抑素C(Cysc)。结果 研究组患者四项指标均较对照组显著增高(P0.01),二项或联合三项检测均较对照组显著增高。结论umA, uβ2-MG, NAG, Cysc是诊断妊娠期高血压疾病患者早期肾脏损伤的敏感指标,联合其中几项指标监测可较早的诊断肾脏损害。 　　[关键词]妊娠期高血压疾病;肾脏损伤;尿微量白蛋白;β2-微球蛋白;N-乙酰-β-D苷酶; 胱抑素C 　　[中图分类号]R714.24+6 [文献标识码]A [文章编号] 1005-0515(2010)-8-015-01 　　 　　Markers of early renal injury in patients with hypertensive disorder complicating pregnancy 　　MeiLifan 　　(BoaiHospital of ZhongShan City,ZhongShan 528403,China) 　　[Abstract]ObjectiveTo investigate diagnostic methods for early renal injury in patients with hypertensive disorder complicating pregnancy. Methods Measured with an automatic biochemical analyzer respectively, urinary microalbumin (mALB), β2-microglodulin(β2-MG), N-acetyl-beta-D-glucosaminidase (NAG) and Cystatin C (Cysc) levels were compared between 72 cases of hypertensive disorder complicating pregnancy(study group) and 53 normal pregnant women (control group). Results The levels of urinary mALB, β2-MG, NAG and Cysc in patients with hypertensive disorder complicating pregnancy were significantly higher than those in the controls ( P 0. 01) . Meanwhile, measuring two or three markers together would raise higher positive rate in patients with hypertensive disorder complicating pregnancy when compared with the control group. Conclusions The method is sensitive to measure urinary mALB, β2-MG, NAG and Cysc in the diagnosis of early renal injury in patients with hypertensive disorder complicating pregnancy. Furthermore, measuring three or four markers together can get a higher positive rate in detecting early injury to kidney in patients with hypertensive disorder complicating pregnancy. 　　[Keywords]hypertensive disorder complicating pregnancy; renal injury; urinary microalbumin; beta2-Microglobulin; N-acetyl-beta-D-glucosaminidase; Cystatin C. 　　 　　妊娠期高血压疾病是妊娠期所特有的疾病。本病发生于妊娠20周以后,临床表现为高血压、蛋白尿、浮肿,严重时出现抽搐、昏迷,甚至母婴