无机化学张天蓝fe.ppt

* 铁超负荷是一种渐进性可危急生命的疾病,经常是频繁输血引起的并发症,过量的铁会损害肝脏,心脏和内分泌腺.铁螯合剂是唯一有效地治疗输血相关铁过负荷的方法 is the only drug available in US to treat iron overload * * Because of short half-life (20 minutes), must be given by continuous infusion 8 to 12 hours/day, 5 to 7 days/week。 Compliance is poor because of side effects and quality-of-life issues Oral therapy is highly desirable。网状内皮组织 * 例如在山梨醇铁注射液（用于例如在山梨醇铁注射液（用于肌肉注射）的处方中， 用柠檬酸结合游离铁离子阻止其水解， 并加入山梨醇结合水解产物控制聚合程度。 * Shows sequence of electron carriers in electron transport chain and the drop in free energy as electrons travel down the chain Electrons removed from food during glycolysis and Krebs cycle are transferred by NADH to first molecule of electron transport chain: Flavoprotein (has prosthetic group called flavin mononucleotide – FMN) In next redox rxn, FMN returns to its oxidized form as it passes electrons to an iron sulfur protein (FeS) Which then passes electrons to ubiquinone (Q – lipid, only one not a protein) Most of remaining carriers are cytochromes (Cyt) Prosthetic group called heme group – has four organic rings surrounding a single iron atoms Similar to iron-containing prosthetic group found in hemoglobin Iron of cytochromes transfers electrons, no oxygen Several types of cytochromes Last one is cyt a3, passes its electrons to oxygen, which also picks of pair of H atoms to form water 量子力学中用公式（2S+1）来表示原子光谱中的谱线条数。如正旋为1/2，逆旋为-1/2： ■ 三重态（Triplet) － 两个电子都为顺旋则 2S+1=3 ■ 单重态或激发态(Singlet)－ 若一个为顺旋 另一个为逆旋则2S+1=1 * * * 利用Fe(III)/Fe(II)周转传递电子把一步4电子氧化还原 变成分四步的单电子氧化还原 * Step-wise reduction of molecular oxygen via 1 electron transfers * 需氧生物用氧分子去氧化食物中的某些成分进行物质/能量代谢时，利用的是氧的单电子氧化作用,利用Fe(III)/Fe(II)周转传递电子把一步4电子氧化还原变成分四步的单电子氧化还原 * Oxygen is a relatively unreactive compound Can be metabolized in vivo to form highly reactive oxidants known as Reactive Oxygen Species (ROS). Increasing evidence suggest