妊娠期高血压疾病胎盘源性vWF与vWF―cp表达及意义.docVIP

妊娠期高血压疾病胎盘源性vWF与vWF―cp表达及意义 　　【摘要】目的 探讨血管性血友病因子（vWF）与血管性血友病因子裂解酶（vWF-cp）在妊娠期高血压疾病胎盘组织中的表达及意义。方法 采用免疫组织化学方法检测妊娠期高血压疾病患者90例（妊娠期高血压组、轻度子痫前期组、重度子痫前期组，各30例）与30名正常妊娠产妇胎盘组织中vWF和vWF-cp的表达。结果 妊娠期高血压组、轻度子痫前期组、重度子痫前期组对比正常妊娠组，vWF在胎盘组织的表达强度显著升高，差异有统计学意义（P0.05）；vWF-cp在胎盘组织里的表达强度显著降低，差异有统计学意义（P0.05）。结论 妊娠期高血压疾病中vWF及vWF-cp的表达水平变化最终导致血管内皮细胞脱落产生胎盘源性改变，从而与妊娠期高血压疾病的发病与病情有关。 　　【关键词】vWF；vWF-cp；胎盘源性子痫前期；妊娠期高血压疾病；免疫组织化学 　　【中图分类号】R587.1 【文献标识码】B 【文章编号】ISSN.2095-6681.2015.009.0.03 　　【Abstract】Objective Study of vWF and vWF-cp expression and significance in placental of hypertensive disorder in pregnancy.Methods Detection of 90 cases of gestational hypertension group by munohistochemical method （30 cases of gestational hypertension； 30 cases of mild preeclampsia； 30 cases of severe preeclampsia） and 30 cases of normal pregnancy the expression of vWF and vWF-cp in the placenta. Results Gestational hypertension； 30 cases of mild preeclampsia； 30 cases of severe preeclampsia compared with normal pregnancy group， the expression intensity of vWF in placenta in significantly increased （P0.05）， with a statistically significant difference between the groups； the expression intensity of vWF-cp in placenta tissue was significantly lower （P0.05）， with a statistically significant difference between the groups.Conclusion The expression levels of vWF and vWF-cp in gestational hypertension disease in patients with damaged vascular endothelial cells in the placenta， the placenta is small， resulting in the pathogenesis of vascular endothelial cell loss hypertension induced apoptosis of placenta derived cells and pregnancy related disease. 　　【Key words】vWF；vWF-cp；The source of placenta in preeclampsia；Hypertensive disorders complicating pregnancy；Immunohistochemistry 　　妊娠期高血压疾病（HDCP，Hypertensive disorders complicating pregnancy）是孕妇所有的一类疾病。[1]是危害孕妇健康和造成胎儿、新生儿死亡的重要疾病之一，是国内外产科专家学者研究的热点课题。HDCP中子痫前期的发生机制可为母源性子痫前期、胎盘源性子痫前期、还存在以上二者同时存在的情况。vWF与vWF-cp，在高血压或糖尿病等疾病患者血浆中变化的相关报告较多，其在HDCP发病过程中的报道较为罕见，本研究以二者在HDCP胎盘组织中