宫腔镜子宫内膜息肉切除术后预防复发临床研究.docVIP

宫腔镜子宫内膜息肉切除术后预防复发临床研究 　　【摘要】 目的：探讨子宫内膜息肉宫腔镜手术后口服去氧烯炔雌醇（妈富隆）和放置左炔诺孕酮宫内缓释系统（曼月乐）两种不同方法对预防复发的效果。方法：选择宫腔镜下子宫内膜息肉切除术并且术后病理证实为子宫内膜息肉的患者247例，随机分为三组：妈富隆组84例为术后口服妈富隆3～6个月，曼月乐组81例为术后放置左快诺孕酮宫内缓释系统，对照组82例为单纯行宫腔镜下子宫内膜息肉切除术。术后随访12个月，观察三组子宫内膜息肉复发和月经情况。结果：妈富隆组复发率5.95%，曼月乐组复发率3.70%，对照组复发率18.29%，妈富隆和曼月乐组与对照组比较，差异有统计学意义（P0.05）；术后3、6、12个月妈富隆组和曼月乐组月经量少的构成比均明显高于对照组（P0.01）。结论：子宫内膜息肉宫腔镜手术后应用妈富隆或曼月乐可有效改善月经过多状况，降低子宫内膜息肉复发率。 　　【关键词】 子宫内膜息肉； 宫腔镜； 复发； 妈富隆； 曼月乐 　　中图分类号 R711.71 文献标识码 B 文章编号 1674-6805（2014）19-0018-02 　　The Clinical Study after Hysteroscopic Endometrial Polypectomy in Preventing Recurrence/QIU Mei-ying.//Chinese and Foreign Medical Research，2014，12（19）：18-19 　　【Abstract】 Objective：To investigate the recurrence-prevention effect of oral Desogestrel and Ethinylestradiol Tablets（Marvelon） or Levonorgestrel-releasing Intrauterine System（Mirena） after hysteroscopic endometrial polypectomy.Method：247 patients who received hysteroscopic endometrial polypectomy and were confirmed with endometrial polyp by postoperative pathological examination，were enrolled into this study.The patients were divided into three groups.Marvelon group（n=84） was given Marvelon Tablets three to six months after the operation.Mirena group （n=81） received Levonorgestrel-releasing Intrauterine System after the operation.And control group（n=82） received no treatment after hysteroscopic endometrial polyectomy.The three groups were followed 12 months after the procedure，and the recurrence rate and menstruation of three groups were compared.Result：The recurrence rate of marvelon group was 5.95%，mirena group was 3.70%，control group was 18.29%，control group had significantly higher recurrence rate than marvelon group and mirena group（P0.05）.The control group had lower proportion of low menstruation volume in three，six，twelve months after the operation than marvelon and mirena group（P0.01）.Conclusion：Oral Marvelon tablets or Levonorgestrel-releasing Intrauterine System after hysteroscopy for endometrial polys sigini