实验动物使用者职业健康与安全OccupationalHealthndSafety.ppt

實驗動物使用者職業健康與安全Occupational Health and Safety in the Care and Use Laboratory Animals 黃彥智 國家實驗動物中心 Email: evan@nlac.org.tw 演講目的 1. 讓學員瞭解人員使用實驗動物之職業健康與安全的風險評估 2. 職業健康與安全應注意事項及適當的防護方法 職業健康與安全之定義(Occupational Health and Safety) Institutional employees, fellows, students and visitors who in the course of their work with research animals might be exposed to hazards that could adversely affect their health and safety. All individuals have direct contact with animals, living tissues, body fluids, wastes…… 從事動物實驗者可能遭遇到的工作傷害 1. Allergens 2. Biological hazards--Zoonotic diseases 3. Physical and chemical hazards 4. Protocol related hazards 職業健康與安全(Occupational Health and Safety) 計畫設計及管理 (Program design and management) 計畫 (Programs): 1. Knowing the hazard 2. Avoiding and controlling exposures 3. Training and education 4. Rules and guidelines 5. Consistency 6. Record keeping and monitoring 7. Commitment and coordination 職業健康與安全(Occupational Health and Safety) 管理 (Management): 1. Animal care and use 2. Research 3. Environmental health and safety 4. Occupational health 5. Administration and management 6. IACUC provide links among the five above institutional functions. 動物房過敏原(Allergens in the Animal Facility) 動物房過敏原(Allergens in the Animal Facility) 主要過敏原 Rats and Mice: urine protein, rat n 1A (pre-albumin), rat n 1B (a2-euglobulin), Mus m 1 (produced in liver and saliva and secreted in urine, 100 times in serum, male 4 times female) Rabbits: Ag-1, fur (glycoprotein, major) ； Ag-2, saliva、urine (minor) Cats: Fel d 1, produced in sebaceous glands of the skin and coats of the hair shafts 動物房過敏原(Allergens in the Animal Facility) 預防 (Prevention): 1. Facility design: HEPA filter, filter top, air changes and HVAC etc., (RH: 54~77%) 2. Work practices (Workers should be made aware of the risks and avoid exposure as much as possible) 3. Personal protective equipment (Once a person develops allergic symptoms, surgical disposable masks are usual