STAT3与肿瘤关系的研究进展陈越，季鸣，陈晓光1（中国医学科学院.PDFVIP

STAT3 肿瘤关系的研究进展 陈越，季鸣，陈晓光*1 （中国医学科学院、北京协和医学院药物研究所，天然药物活性物质与功能国家 重点实验室，北京 100050） 摘要: 信号传导与活化转录因子 3 （signal transducers and activators of transcription, STAT3 ）是信号传导活化转录因子家族的重要成员，在细胞中起到 传递信号和启动基因转录的双重作用。许多研究已经证明组成型 STAT3 在多种 人类肿瘤中激活。有证据表明，异常STAT3 信号通过抑制凋亡，诱导细胞增殖、 血管生成、侵袭和转移，诱发炎症和免疫抑制来促进人类癌症的发生和进展。目 前针对 STAT3 为靶点开发出一些特异性小分子抑制剂，然而还没有药物进入临 床阶段。鉴定和开发靶向抑制 STAT3 激活的新型药物仍然是一个重要的科学和 临床挑战。本文介绍了STAT3 与肿瘤发生之间的关系及新的STAT3 抑制剂的研 究进展。 关键词: 肿瘤发生；信号传导活化转录因子3 ；细胞增殖 中图分类号: R966 文献标识码: A 文章编号: 0513-4870(2017) Research progress of relationship between STAT3 and tumor CHEN Yue ，JI Ming ，CHEN Xiao-guang* (State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China) Abstract: Signal transducers and activators of transcription (STAT3) is an important member of the family of signal transducers and activators of transcription, and plays a dual role in signaling and initiating gene transcription in cells. Numerous studies have demonstrated constitutive activation of STAT3 in a wide variety of human tumors. There is strong evidence to suggest that aberrant STAT3 signaling promotes initiation and progression of human cancers by either inhibiting 收稿日期: 2017-04-12; 修回日期: 2017-05-16. 基金项目: 中国医学科学院医学与健康科技创新工程 （20 16-12M-3-008 ）. *通讯作者Tel/Fax: 86-10 E-mail: chxg@imm.ac.cn DOI: 10.16438/j.0513-4870.2017-0354 1 apoptosis or inducing cell proliferation, angiogenesis, invasion, metastasis, inflammation and immunosuppression. At present, some specific small molecule inhibitors have been developed by targeting STAT3, however, no drugs have been used in clinical