喉部鼻型NKT 细胞淋巴瘤一例临床分析并文献复习教学.docVIP

喉部鼻型NK/T细胞淋巴瘤一例临床分析并文献复习 Phundreimayum Raees Ahmed1，谢敏2 【摘要】目的 研究喉部鼻型NK/T细胞淋巴瘤的临床表现、病理特点及免疫表型，提高对本病的认识。 方法 对收治的1例喉部鼻型NK/T细胞淋巴瘤进行介绍，并对2001年至2012年国内发表的该病报道进行回顾性分析。结果 纳入8篇报道共10例确诊为喉部鼻型NK/T细胞淋巴瘤患者。患者多中年起病，临床表现多样，最常见首发症状为声音嘶哑（80%）。病变最常累及的部位为声带（87.5%），出现表面增生或浸润性肿块（85.7%）、粘膜肿胀（57.1%）。其镜下最常见表现为大片坏死组织，淋巴细胞增生活跃（55.6%）。免疫组化CD45RO、TIA-1、EBER1/2的阳性率均为100%，而CD56、粒酶B的阳性率为75%。结论 喉部鼻型NK/T细胞淋巴瘤的临床表现多样，但其具有独特的病理、免疫学特点。 【关键词】喉部；鼻型NK/T细胞淋巴瘤；临床分析 Clinical Analysis of 1 Case of Laryngeal Nasal-NK/T-Cell Lymphoma with Literature Review PHUNDREIMAYUM Raees Ahmed1, XIE Min2 1 Department of Respiration, Jawaharlal Nehru Hospital, Imphal, Manipur, India 2 Department of Respiration, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China Abstract Objective: To improve the understanding of Laryngeal Nasal-NK/T-Cell Lymphoma by analyzing its clinical, pathological and immunohistochemical characteristics. Methods: Full description of 1 case of laryngeal nasal-NK/T-cell Lymphoma was given, and domestic reports of it between year-2001 to 2012 were retrospectively analyzed. Results: 8 reports with 10 cases were collected. Most patients were affected in their middle age (90%) with onset age varied around 39.0 (±10.6) years old, and died of peripheral respiratory failure. Most common initial symptom was hoarseness (80%). Patients’ clinical manifestations varied, which included hoarseness (80%), sore throat or foreign body sensation (70%), fever (50%), hemoptysis (40%) and so on. The diagnosis relied on the biopsy and its pathological, immunohistochemical, hybridization in situ tests. The most commonly involved lesion was located in vocal cords (87.5%), which presented with superficial hyperplasia or invasive mass (85.7%), mucosal swelling (57.1%). Scattered allotyped cells buried in the background of necrotic tissue was most commonly seen under microscope, with foliated-located active hyperplasic lymphocytes (55.6%). In immunohistochemistry, CD45RO, TIA-1, EBER1/2 have the 100% posit