注射用丹参多酚酸盐在糖尿病周围神经病变临床应用.docVIP

注射用丹参多酚酸盐在糖尿病周围神经病变临床应用 　　摘要：目的 探讨应用注射用丹参多酚酸盐、甲钴胺治疗糖尿病周围神经病变的临床效果。方法 将2014年1月～2016年9月西宁市第一人民医院收治的180例DPN患者按照随机数字表法分为两组，每组90例。两组患者均予以降血压、控制血糖等基础治疗，对照组在基础治疗的同时给予甲钴胺片，治疗组予以注射用丹参多酚酸盐联合甲钴胺，疗程3 w，比较治疗前后两组患者血清高敏C-反应蛋白（hs-CPR）、一氧化氮（NO）、肿瘤坏死因子-α（TNF-α）、血浆粘度、血浆纤维蛋白原等水平变化，并比较治疗前后两组皮肤交感反应、肢体运动神经及感觉神经传导速度变化。结果 与治疗前比较，对照组上述血清学指标较治疗前无明显变化（P0.05），治疗组血清NO升高（P0.05），其余指标均较治疗前下降（P0.05）；治疗后两组体现神经功能参数均较治疗前升高（P0.05），且治疗组明显高于对照组（P0.05）。结论 注射用丹参多酚酸盐应用于DPN的治疗可改善血管内皮细胞功能和血液黏度，利于神经功能恢复，延缓DPN的进展，其机制可能与减少炎性因子的分泌、降低血液流变学指标有关。 　　关键词：丹参多酚酸盐；糖尿病周围神经病变；炎症因子；血液粘稠度 　　中图分类号：R587.2 文献标识码：A 文章编号：1006-1959（2017）18-0061-03 　　Abstract：Objective To explore the application of salvianolate injection，clinical effect of mecobalamin on diabetic peripheral neuropathy.Methods From January 2014 to September 2016，180 patients with DPN were enrolled in the first peoples hospital of Xining city.The patients were divided into two groups according to the random number table method，90 cases in each group.Two groups of patients were given lower blood pressure，control of blood glucose and other basic treatment，the control group in the basic treatment at the same time to give mecobalamin tablets，patients in the treatment group were treated with salvianolate injection combined with Mecobalamin，treatment for 3 w，comparing the two groups before and after treatment of serum high-sensitivity C-reactive protein（hs-CPR），nitric oxide（NO）），tumor necrosis factor-α（TNF-α），plasma viscosity，plasma fibrinogen level changes before and after treatment were compared in two sympathetic skin response group，limb motor nerve and sensory nerve conduction velocity changes. Results Compared with before treatment，the control group of the serological index before treatment had no significant change（P0.05），the treatment group increased serum NO（P0.05），the other indexes were lower than before treatment（P0.05）；the two groups after treatment of nerve function parameters were higher than before treatment（P0.05），and the treatment group was significantl