不同剂量埃索美拉唑为基础的三联疗法对幽门螺杆菌的根除疗效及其对阿莫西林胃内分布影响的初步分析-内科学(消化系病)专业论文.docxVIP

安徽医科大学硕士学位论文 2.1.5 Hp 根除疗效影响因素的 logistic 回归分析 15 2.1.6 药物不良反应················································································17 2.2 高剂量与标准剂量埃索美拉唑为基础三联疗法对阿莫西林胃内浓度分布影响的初步研 究········································································17 2.2.1 试验病例的基本资料·····································································17 2.2.2 幽门螺杆菌根除情况·····································································18 2.2.3 人体血浆、胃液、胃粘膜组织内阿莫西林浓度的测定方法（HPLC 方法）的精确 性 18 2.2.4 高剂量组和标准剂量组患者血浆、胃液、胃粘膜组织内阿莫西林浓度分布的特 点························································································22 3.讨论········································································································24 3.1 高剂量与标准剂量埃索美拉唑为基础的三联疗法根除 Hp 疗效的比 较 24 3.2 含左氧氟沙星三联疗法与标准三联疗法一线根除 Hp 疗效的比 较 26 3.3不同临床疾病对Hp根除疗效的影响 28 3.4 高剂量组和标准剂量组患者血浆、胃液、胃粘膜组织内阿莫西林浓度分布的特 点····························································································29 3.5 三联疗法中高剂量与标准剂量 PPI 对阿莫西林在胃内浓度分布的影响以及与幽门螺杆菌根 除疗效的关系 30 4.结论········································································································31 5.参考文献·································································································32 6.附录········································································································39 7.致谢········································································································40 8．综述·········································································································41 9.参考文献·································································································54 2 安徽医 安徽医科大学硕士学位论文 PAGE PAGE 1 英文缩略词表 英文缩写 英文全称 中文全名 Hp helicobacter pylori 幽门螺杆菌 PPI proton pump inhibitor 质子泵抑制剂 PUD peptic ulcer diseases 消化性溃疡 CG chronic gastritis 慢性胃炎 ITT intention-to-treat analyses 意向处理分析 PP per-protocol analyses 符合方案分析 HPLC high performance liquid chromato