不同发育阶段大通牦牛大脑皮质组织学研究基础兽医学专业论文.docxVIP

青海大学硕士学位论文摘要 青海大学硕士学位论文 摘要 II II 经元数密度随年龄增长逐渐减小；牦牛和黄牛大脑皮质微血管密度均体现出随 年龄增长而逐渐增加的趋势，但牦牛大脑皮质微血管密度显著高于相同年龄的 黄牛；牦牛大脑皮质中 HIF-1α 和 VEGF 的表达均表现出先增加再减少的趋势。 关键词：牦牛 神经元 微血管密度 HIF-1α VEGF 青海大学硕士学位论文Abstr 青海大学硕士学位论文 Abstract III III Abstract In order to reveal the developmental characteristics, morphous of cerebral cortex in Da Tong yaks and plain cattles were observed and meaured using histological methods. Distribution and expression of HIF-1α and VEGF in yak cerebral cortex, and the microvessel density were detected with immunohistochemistry. Results were shown as follows: The thickness of the occipital、frontal and parietal lobe cortices in yaks increased gradually with age after birth. The thickness of temporal lobe cortex was highest at 180 day, slightly higher than the adult, but the difference was not significant (P0.05). Occipital cortex at 180 days and adulthood were thicker significantly than that at 30 days; frontal and parietal cortical thickness at adult yak were significantly higher than the other three groups (P0.05). The thickness of the cattle occipital、frontal、parietal and temporal lobe were increased with age after birth. Occipital、frontal and temporal lobe cortical thickness at 30 days,180 days and adulthood were higher significantly than that at 1 day(P 0.05). Temporal lobe cortical thickness at 180 days and adulthood were higher significantly than that at 1 day and 30 days (P0.05). Neuron numerical density of the frontal、parietal and temporal lobe cerebral cortex in the yak were decreased gradually with age. Neuron numerical density of the frontal and parietal cortex in 1-day-old yak were higher significantly than other three groups. The neuron numerical density of occipital cortex in 1-day and 30-days old yak was strikingly higher than that in 180-days-old and adult yak. The neuron numerical density of parietal cortex in 1-day-old yak was significantly higher than that in 180-days-old and adulthood yak(P0.05). Neuron numerical density of the