不同剂量阿托伐他汀对心肌急性缺血再灌注损伤后线粒体功能的影响-内科学专业论文.docxVIP

than the first day in two groups (P0.01); The content of FFA in 40mg atorvastatin group is less than 20mg atorvastatin group after postoperative seventh day , the difference was statistically significance (P0.05); (5) The CF-6 levels in 40mg atorvastatin group after postoperative seventh day is lower than the 20mg atorvastatin group, the difference was statistically significant (P0.05), The content of CF-6 after postoperative seventh day is lower than the first day in two groups (P0.05); the difference was statistically significance (P0.05); (6) The content of P53 in 40mg atorvastatin group after postoperative seventh day is lower than the 20mg atorvastatin group, the difference was statistically significant (P0.05); The content of P53 after postoperative seventh day is lower than the first day in both two groups (P0.05); the difference was statistically significance (P0.05); (7) Reperfusion arrhythmias were occurd in both two groups, the rate of reperfusion arrhythmias in 40mg atorvastatin group is higher than the 20mg atorvastatin group (P0.05); (8) Percentage of TIMI 3 flow achieved in IRA after PCI between the two groups, they had no significant difference(P＞0.05), No-reflow didn’t occur in both grou,two groups 90 minutes after PCI, ST segment was no statistically significant difference (P0.05); (9)There were no difference in the rate of myocardial re-infarction, target vessel revascularization,shock and death during hospitalization between two groups.Conclusion Atorvastatin can reduce cytokine , oxygen free radical formation and reduce cardiac myocyte apoptosis to protect mitochondrial function, thereby relieve the ischemic reperfusion injury in patients who AMI after direct PCI, and they can improve the patients clinical outcomes in the near future. Key Words: Atorvastatin；ischemia and reperfusion injury；percutaneous transluminal coronary intervention；mitochondria；AMI Directed by :Professor: Zheng Yuyun Applicant for Master degree: Wang Yakun (Department of