帕瑞昔布钠用于腹腔镜异位妊娠手术临床观察.docVIP

帕瑞昔布钠用于腹腔镜异位妊娠手术临床观察 　　[摘要] 目的 探讨帕瑞昔布钠对腹腔镜异位妊娠手术全麻拔管期血流动力学以及术后疼痛的影响。 方法 选择2015年1月1日～5月31日期间因异位妊娠需行腹腔镜手术治疗的患者80例，年龄20～45岁，ASAⅠ～Ⅱ级。采用随机数字表法将患者随机分为帕瑞昔布钠组（P组）和对照组（C组）。气管插管后手术开始前P组静脉注射帕瑞昔布钠40 mg，C组静脉注射等剂量的生理盐水，观察两组用药前、拔管前、拔管时、拔管后5 min和拔管后10 min的HR、SBP和DBP，观察并记录患者术后30 min、1 h、2 h、4 h、6 h和12 h的VAS评分。 结果 与C组比较，P组患者的SBP和DBP在拔管前、拔管时、拔管后5 min和拔管后10 min均明显降低（P0.05）。 结论 手术开始前静脉注射帕瑞昔布钠40 mg，能有效维持腹腔镜异位妊娠手术全麻拔管期间的血流动力学平稳，并能有效缓解患者的术后疼痛，提高患者的舒适度。 　　[关键词] 帕瑞昔布钠；异位妊娠；腹腔镜；血流动力学；术后疼痛 　　[中图分类号] R614；R714.22 [文献标识码] B [文章编号] 1673-9701（2015）30-0101-03 　　Clinical observation of parecoxib sodium in laparoscopic surgery for ectopic pregnancy 　　LIU Dongjun ZHANG Yu 　　Department of Anesthesiology， Shenyang Womens and Childrens Hospital， Shenyang 110011， China 　　[Abstract] Objective To investigate the effects of parecoxib sodium in hemodynamics during extubation of general anesthesia period and postoperative pain of laparoscopic surgery for ectopic pregnancy. Methods A total of 80 cases of patients who demanded for ectopic pregnancy laparoscopic surgery from January 1st to May 31st in 2015 were chosen， aging from 20 to 45 years old， with ASA ranging from Ⅰ to Ⅱ level. Random number table was used to divide the patients into the parecoxib sodium group （group P） and the control group（group C）. After tracheal intubation and before the start of the surgery， group P received intravenous injection of 40 mg parecoxib sodium， and group C received intravenous injection of the same dose of saline. SBP and DBP of the two groups before intravenous injection， before extubation， on extubation， 5 min and 10 min after extubation were observed， and VAS scores of patients 30 min， 1 h， 2 h， 4 h， 6 h and 12 h after surgery were observed and recorded. Results Compared with those in group C， SBP and DBP of patients in group P， before extubation， on extubation， 5 min and 10 min after extubation significantly reduced（P0.05）. Conclusion Intravenous injection of 40 mg parecoxib sodium before surgery can effectivel