异丙托溴铵对小儿哮喘患者白细胞介素13转化生长因子β1及血管内皮生长因子表达影响.docVIP

异丙托溴铵对小儿哮喘患者白细胞介素13转化生长因子β1及血管内皮生长因子表达影响 　　[摘要] 目的 探讨异丙托溴铵对小儿哮喘患者血清白细胞介素13（IL-13）、转化生长因子β1（TGF-β1）、血管内皮生长因子（VEGF）表达的影响。 方法 选取2013年12月～2015年10月于湖北医药学院附属太和医院就诊的小儿哮喘患者60例作为研究对象，将所有患者随机分为实验组和对照组，每组各30例。对照组患者使用沙丁胺醇及氨茶碱进行治疗，实验组在对照组治疗的基础上加用异丙托溴铵。治疗前后检测IL-13、TGF-β1、VEGF及肺功能水平，同时比较两组治疗后临床总有效率。 结果 与治疗前比较，两组患者治疗后血清IL-13、TGF-β1、VEGF水平明显降低，第1秒用力呼气容积（FEV1）和FEV1/用力肺活量（FVC）明显提高，差异均有统计学意义（P 0.05）。实验组治疗后血清IL-13、TGF-β1、VEGF水平明显低于对照组，FEV1和FEV1/FVC明显高于对照组，临床总有效率也明显高于对照组，差异均有统计学意义（P 0.05）。 结论 异丙托溴铵能够改善小儿哮喘患者的肺功能，提高临床疗效，推测其机制可能与降低患者血清IL-13、TGF-β1、VEGF水平有关。 　　[关键词] 异丙托溴铵；小儿；哮喘；白细胞介素13；转化生长因子β1；血管内皮生长因子 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1673-7210（2016）06（c）-0149-05 　　[Abstract] Objective To investigate the effect of Ipratropium Bromide for the expression of interleukin 13 （IL-13）， transforming growth factor-β1 （TGF-β1） and vascular endothelial growth factor （VEGF） in children with asthma. Methods Sixty children with asthma treated in Taihe Hospital Affiliated to Hubei University of Medicine from December 2013 to October 2015 were selected as research objects， and they were randomly divided into the experiment group and the control group， with 30 cases in each group. The control group was treated by Salbutamol and Aminophylline， on basis of the control group， the experiment group was added with Ipratropium Bromide. The levels of IL-13， TGF-β1， VEGF and pulmonary function of the two groups before and after treatment were detected， at the same time， the clinical total effective rates of the two groups after treatment were compared. Results Compared with before treatment， the levels of IL-13， TGF-β1， VEGF of the two groups after treatment were significantly decreased， the forced expiratory volume in one second （FEV1） and FEV1/forced vital capacity （FVC） were significantly increased， the differences were all statistically significant （P 0.05）. The levels of IL-13， TGF-β1， VEGF of experiment group after treatment were all lower than those of control group， the FEV1 and FEV1/FVC were highe