左炔诺孕酮炔雌醇对多次人工流产后宫腔粘连患者子宫内膜血管内皮生长因子受体表达影响研究.docVIP

左炔诺孕酮炔雌醇对多次人工流产后宫腔粘连患者子宫内膜血管内皮生长因子受体表达影响研究 　　【摘要】目的 探讨左炔诺孕酮炔雌醇(三相片)对多次人工流产后宫腔粘连患者子宫内膜血管内皮生长因子受体（VEGFR）表达的影响。方法 选择2009年1月~2010年9月我站行多次人工流产而出现宫腔粘连的患者84例，随机分为对照组41例，研究组43例，所有患者行宫腔镜手术。研究组在术后当晚开始服用左炔诺孕酮炔雌醇（三相）片治疗，对照组进行咨询，持续3个月。采用酶联免疫吸附法(ELISA)测定两组患者血清中子宫内膜血管内皮生长因子受体VEGFR-1(flt-1)、VEGFR-2(KDR)、VEGFR-3(flt-4)。比较两组治疗前、治疗后的变化。结果 两组均没有重度粘连。研究组宫腔粘连发生率为7.89%，而对照组宫腔粘连发生率为21.62%。两组比较有显著差异，有统计学意义（p0.05）。两组与治疗前比较，VEGFR-1(flt-1)、VEGFR-2(KDR)、VEGFR-3(flt-4)均下降明显。数据显著差异，有统计学意义（p0.05）。与对照组比较，VEGFR-1(flt-1)、VEGFR-2(KDR)、VEGFR-3(flt-4)均下降明显减低，数据显著差异，有统计学意义（p0.05）。结论 左炔诺孕酮炔雌醇对多次人工流产后宫腔粘连患者子宫内膜血管内皮生长因子受体具有下调作用。 　　【关键词】左炔诺孕酮炔雌醇 人工流产 宫腔粘连 VEGFR-1(flt-1)、VEGFR-2(KDR)、VEGFR-3(flt-4) 　　中图分类号：R711文献标识码：A文章编号：1005-0515（2011）11-010-02 　　【Abstract】Objective To investigate the levonorgestrel ethinyl estradiol (three photos) on many occasions, patients abortion intrauterine adhesions after endometrial vascular endothelial growth factor receptor (VEGFR) expression. Methods January 2009 - September 2010 I stood there in numerous abortions and intrauterine adhesions 84 patients were randomly divided into control group, 41 cases of 43 patients, all patients underwent hysteroscopic surgery. Research group in the evening after taking levonorgestrel ethinyl estradiol starting (phase) in treatment and control group for consultation for three months. Enzyme-linked immunosorbent assay (ELISA) determination of two patients in endometrial vascular endothelial growth factor receptor VEGFR-1 (flt-1), VEGFR-2 (KDR), VEGFR-3 (flt-4). Were compared before treatment, after treatment change. Results Both groups were no severe adhesions. Research Group 7.89% incidence of intrauterine adhesions, while the control group 21.62% incidence of intrauterine adhesions. There were significant differences between the two groups, was statistically significant (p 0.05). Two groups before treatment, VEGFR-1 (flt-1), VEGFR-2 (KDR), VEGFR-3 (flt-4) decreased significantly. Significant differences in the data, was statistically si