子痫前期患者胎盘组织中hif-1α及hsp-27的表达及意义-expression and significance of hif - 1α and hsp - 27 in placenta of preeclampsia patients.docx

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子痫前期患者胎盘组织中hif-1α及hsp-27的表达及意义-expression and significance of hif - 1α and hsp - 27 in placenta of preeclampsia patients.docx

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子痫前期患者胎盘组织中hif-1α及hsp-27的表达及意义-expression and significance of hif - 1α and hsp - 27 in placenta of preeclampsia patients

PAGE PAGE 8 ①HI F- 1αI mmunohi st ochemi st r y showed t hat HI F- 1α pr edomi nant l y l ocal i zed i n nucl eus of t r ophocyt e. The degr ee of st ai ni ng became st r on ger wi t h aggr avat i on of t he di sease, and t he di ff er ence i s si gni f i cant ( P0. 01) . ②HI F- 1α West er n bl ot showed t hat t he l evel of t he expr essi on of HI F- 1αi ncr eased i n mi l d pr eecl ampsi a and sever e pr eecl ampsi a gr oup, c ompar ed wi t h t hat i n nor mal gr oup, i t had posi t i ve corr el at i on wi t h ag gr avat i on of t he di sease, and t he di ff er ence i s si gni f i cant ( P0. 01) . ③HSP- 27 I mmunohi st ochemi st r y showed t hat HSP- 27 pr edomi nant l y l o cal i zed i n kyt opl asm of t r ophocyt e, The degr ee of st ai ni ng became st r o nger wi t h aggr avat i on of t he di sease, and t he di ff er ence i s si gni f i can t ( P0. 01) . ④HSP- 27 West er n bl ot showed t hat t he l evel of t he expr essi on of HSP- 27 i ncr eased i n mi l d pr eecl ampsi a and sever e pr eecl ampsi a gr oup, compar ed wi t h t hat i n nor mal gr oup, i t had posi t i ve corr el at i on wi t h a ggr avat i on of t he di sease, and t he di ff er ence i s si gni f i cant ( P0. 01) . ⑤The r esul t of corr el at i on bet ween t he expr essi on of HI F- 1α and HSP- 27 showed t hat HI F- 1αhad posi t i ve corr el at i on wi t h HSP- 27(r =0. 92 8) . Concl usi ons ①we f ound t hat t he expr essi on of HI F- 1αi ncr eased i n pl acent a t r ophocyt e of pr egnant women compl i cat ed wi t h pr eecl ampsi a, whi ch mani f e st ed t he pl acent a hypoxi a, HI F- 1α may be r el evant wi t h pr eecl ampsi a o nset and i t ’s cl i ni cal sympt oms. ②we f ound t hat t he expr essi on of HSP- 27 i ncr eased i n pl acent a t r ophocyt e of pr egnant women compl i cat ed wi t h pr eecl ampsi a, whi ch mani f e st ed HSP- 27 st r ess expr essi on i ncr eased i n t he hypoxi a st r i ngent st at e，t hen ant i oxi dant s