探究奥美拉唑对口服拜阿司匹林引起胃肠道反应防治效果.docVIP

探究奥美拉唑对口服拜阿司匹林引起胃肠道反应防治效果 　　[摘要] 目的 探究奥美拉唑对口服拜阿司匹林引起的胃肠道反应的防治效果。 方法 随机选取该院 2012年10月―2013年5月期间收治的60例老年心血管疾病患者的相关临床资料综合分析，并将其按照就诊时间随机分为观察组和对照组，两组患者均采用口服小剂量拜阿司匹林治疗，剂量为100 mg/d。因服药后，患者出现了不同程度的胃肠道反应症状，将观察组患者予以质子泵抑制剂奥美拉唑口服：20 mg/次，2次/d，对照组则不予奥美拉唑或其他治疗措施，比较 2 组患者的临床疗效。结果观察组使用口服奥美拉唑肠溶片治疗，对拜阿司匹林引起的胃肠道反应方面起到了明显改善作用，且减轻了患者痛苦，观察组患者有效28例，有效率为93.3%，对照组患者有效仅18例，有效率为60.0%，观察组临床总显效率明显高于对照组，组间比较差异有统计学意义（P0.05）且观察组症状改善时间为（6.14±1.23） d，对照组时间为（10.57±2.39） d，观察组在患者症状改善时间方面优于对照组。结论 采用奥美拉唑治疗对口服拜阿司匹林引起的胃肠道反应方面的效果，具有较高的临床价值。 　　[关键词] 奥美拉唑；拜阿司匹林；心血管疾病；胃肠道反应 　　[中图分类号] R973 [文献标识码] A [文章编号] 1674-0742（2015）08（b）-0125-02 　　[Abstract] Objective To explore the preventive effect of omeprazole on gastrointestinal reaction caused by oral administration of aspirin. Methods The relevant clinical data comprehensive analysis method of 60 cases of disease of patients admitted during the period from October 2012 to May 2013 in our department aged cardiovascular， and in accordance with the time of treatment were randomly divided into observation group and control group， two patients were treated with low-dose oral aspirin therapy， the dose of 100 mg/d. Because after medication， patients had gastrointestinal symptoms in different degree， the patients in observation group were given omeprazole orally： 20 mg/ times， 2 times /d， while the control group has no omeprazole or other treatment， compared the clinical efficacy of 2 groups. Results Observation group use omeprazole enteric coated tablets in the treatment， the aspirin caused gastrointestinal reactions to significantly improve and reduce the pain of patients， in the observation group were 28 cases were effective， efficient 93.3%， the patients in the control group only 18 cases， effective 60.0% in the observed group， the clinical total effective rate was significantly higher than that of the control group， the difference between， the two groups has statistical significance （P0.05） and observation group symptom improvement time （6.14±1.23） d， the control