新生儿颅内出血应用神经节苷脂钠治疗临床效果.docVIP

新生儿颅内出血应用神经节苷脂钠治疗临床效果 　　【摘要】 目的：探讨新生儿颅内出血应用神经节苷脂钠治疗的临床效果。方法：选取2012年 　　7月-2015年7月本院收治的颅内出血新生儿128例作为研究对象，随机分为对照组和试验组，每组64例。对照组进行常规降颅压及止血治疗，试验组在对照组治疗基础上给予神经节苷脂钠对症治疗，比较两组治疗总有效率、新生儿不良结局及神经测定（NABA）评分。结果：试验组治疗总有效率98.44%、不良结局发生率10.93%、治疗后神经测定评分（40.99±3.26）分均优于对照组的71.88%、40.63%及（38.71±3.99）分，比较差异均有统计学意义（P0.05）。结论：应用神经苷脂钠联合传统降压止血方式对颅内出血患儿进行治疗能够有效缓解病情，减少新生儿不良结局的发生，但远期的临床效果仍然需要通过延长随访时间和加大样本量来进行证实。 　　【关键词】 新生儿； 颅内出血； 神经节苷脂钠 　　【Abstract】 Objective：To investigate the clinical effect of neonatal treatment application of Ganglioside sodium for intracranial hemorrhage.Method：A total of 128 cases of neonatal intracranial hemorrhage from July 2012 to July 2015 in our hospital were selected as the research objects，they were randomly divided into the control group and the experimental group，each group had 64 cases.The control group was given routine antihypertensive and hemostatic treatment，the experimental group was treated with Ganglioside sodium treatment based on the treatment in control group，the total effective rate，the neonatal adverse and neurological assessment （NABA） score in two groups were compared.Result：The experimental group total efficiency rate was 98.44%，the outcomes reactions was 10.93%，neurological score was （40.99±3.26） score，significantly better than the control group 71.88%，40.63% and （38.71±3.99） score，the differences were statistically significant（P0.05）.Conclusion：The application of Ganglioside sodium combined with conventional antihypertensive therapies can effectively alleviate hemostatic condition of children with intracranial hemorrhage，greatly reduce the neonatal adverse outcomes，but the long-term clinical results still need by extending the follow-up time and inreasing sample size to confirm. 　　【Key words】 Newborn； Intracranial hemorrhage； Ganglioside sodium 　　First-author’s address：The Provincial Clinical Hospital of Fujian Medical University，Fujian Provincial Hospital，Fuzhou 350004，China 　　doi：10.3969/j.issn.1674-4985.2016.11.013 　　新生儿颅内出血是指新生儿在