曲美他嗪对慢性心力衰竭患者临床效果影响.docVIP

曲美他嗪对慢性心力衰竭患者临床效果影响 　　[摘要]目的 观察曲美他嗪对慢性心力衰竭（CHF）患者的临床疗效，探讨其治疗CHF的机制。方法 选取我院2016年2月～2017年2月收治的100例CHF患者作为研究对象，随机分为治疗组和对照组，每组各50例。对照组患者接受基础治疗（ACEI、洋地黄、利尿剂、β受体阻滞剂），治疗组加用曲美他嗪。随访3个月后观察治疗的有效率、左室射血分数（LVEF）、左室收缩末期容积（LVDS）、左室舒张末期容积（LVDD）、血浆脑钠肽（NT- proBNP）的变化。结果 治疗组患者的临床总有效率均高于对照组，差异有统计学意义（P0.05），治疗组患者的左室舒张及收缩末期末径缩小，左室射血分数上升，NT- proBNP水平下降，改善情况优于对照组，差异有统计学意义（P0.05）。结论 在以传统心衰治疗的基础上使用曲美他嗪治疗慢性心力衰竭能显著改善患者的左心重构及左心功能。 　　[关键词]曲美他嗪；慢性心力衰竭；效果 　　[中图分类号] R541.61 [文献标识码] A [文章编号] 1674-4721（2018）1（b）-0123-03 　　[Abstract]Objective To evaluate the effects of Trimetazadine on patients with chronic heart failure.Methods 100 patients with chronic heart failure treated in our hospital form February 2016 to February 2017 were selected as the subjects，and divided into therapy group and control group，50 cases in each group.The control group patients were given basic treatment with angiotensin converting enzyme inhibitor（ACEI），digitalis，diuretics，βblock.And the therapy group were given Trimetazadine in addition to the basic treatment.Heart function，LVEF，LVDD，LVDS and BNP level in those patients were observed before and after three months treatment.Results Compared with the control group，the total effective rate increased significantly in the therapy group.After treatment，the LVEF of the patients was obviously improved，and RHR in therapy group was decreased.LVDD，LVDS and BNP level also decreased at 3 months compared with those in therapy group，the difference was statistically significant （P0.05）.Conclusion In additional to the conventional therapy，Trimetazadine can improve the left ventricular performance and remodeling in patients with coronary heart failure. 　　[Key words]Trimetazadine；Coronary heart disease（CHF）；Effecacy 　　慢性充血性心力衰竭（CHF）?楦髦制髦市孕脑嗖』颊叩闹漳┙锥危?是致死率和致残率极高的临床常见的综合征。现代心衰治疗以血管紧张素转换酶抑制剂（ACEI）、醛固酮受体拮抗剂、洋地黄、β受体阻滞剂等综合治疗为主，能改善CHF心衰患者的长期预后。曲美他嗪是一种有效的抗心绞痛药物[1]， 具有抗氧自由基作用，通过优化线粒体能量代谢来治疗慢性心力衰竭，大量的临床研究提示，曲美他嗪在心力衰竭的治疗中具有良好的疗效。本研究选取100例慢性心力衰竭患者作为研究对象进行对照临床试验，旨在为临床CHF患者的治疗以及曲美他嗪的应用提供客观依据，现报道如下。