氯吡格雷联合阿托伐他汀治疗不稳定型心绞痛临床观察.docVIP

氯吡格雷联合阿托伐他汀治疗不稳定型心绞痛临床观察 　　[摘要] 目的 探讨氯吡格雷联合阿托伐他汀治疗不稳定型心绞痛的临床疗效。 方法 选取2014年6月～2016年6月在我院住院治疗的不稳定型心绞痛患者60例，采用随机数字表法分为两组，每组30例，两组患者均给予硝酸甘油、β受体阻滞剂、钙通道阻滞剂、阿司匹林等常规对症治疗，观察组同时联合阿托伐他汀、氯吡格雷，疗程4周。比较两组疗效及血脂指标的变化情况。 结果 观察组的临床总有效率为96.7%，对照组的临床总有效率为70.0%，两组比较，差异有统计学意义（P0.05）。治疗后，观察组患者的TC为（4.23±1.12）mmol/L、TG为（1.61±0.55） mmol/L、LDL-C为（2.79±0.41）mmol/L、HDL-C为（1.28±0.37）mmol/L，分别与对照组比较，差异均有统计学意义（P0.05）。 结论 氯吡格雷联合阿托伐他汀治疗不稳定型心绞痛临床疗效确切，可以显著降低血脂水平，值得推广和应用。 　　[关键词] 不稳定型心绞痛；氯吡格雷；阿托伐他汀；血脂 　　[中图分类号] R541.42 [文献标识码] B [文章编号] 1673-9701（2017）27-0046-03 　　Clinical observation of clopidogrel combined with atorvastatin in the treatment of unstable angina 　　WANG Jinlong 　　Department of Internal Medicine， Beidaihe Sanatorium of Beijing Military Region（281 Hospital）， Qinhuangdao 066100， China 　　[Abstract] Objective To investigate the clinical efficacy of clopidogrel combined with atorvastatin in the treatment of unstable angina pectoris. Methods A total of 60 patients with unstable angina who were hospitalized in our hospital from June 2014 to June 2016 were selected. They were assigned to two groups according to the random number table， with 30 patients in each group. Both groups were given nitroglycerin， β-blockers， calcium channel blockers， aspirin and other conventional symptomatic treatment. The observation group was given atorvastatin and clopidogrel at the same time for 4 weeks. The efficacy and changes in blood lipid index were compared between the two groups. Results The total clinical effective rate in the observation group was 96.7%， and the total effective rate in the control group was 70.0%， there was significant difference between the two groups （P0.05）. After treatment， the level of TC in the observation group was（4.23±1.12） mmol/L， TG was（1.61±0.55） mmol/L， LDL-C was （2.79±0.41） mmol/L， and HDL-C was（1.28±0.37） mmol/L. Compared with the control group， there were significant differences between the two groups（P0.05）. Conclusion Clopidogrel combined with atorvastatin is effectiv