环磷酰胺与泼尼松联合治疗特发性间质性肺炎效果分析.docVIP

环磷酰胺与泼尼松联合治疗特发性间质性肺炎效果分析 　　[摘要]目的 研究?h磷酰胺与泼尼松联合治疗特发性间质性肺炎的临床效果。方法 选取2015年2月～2016年9月我院收治的60例特发性间质性肺炎患者作为研究对象，根据收治时间先后顺序将其分为对照组和观察组，每组各30例。对照组患者采用泼尼松治疗，观察组患者在对照组治疗基础上联合环磷酰胺进行治疗。观察对比两组患者的治疗总有效率、不良反应发生率、肺功能指标、治疗前后睡眠质量评分及生活质量评分。结果 观察组患者的治疗总有效率（96.67%）高于对照组（70.00%），不良反应发生率（6.67%）低于对照组（30.00%），各项肺功能指标（PEF、MVV、FVC）均高于对照组，差异有统计学意义（P0.05）。治疗后，观察组患者的睡眠质量评分低于对照组，生活质量评分高于对照组，差异均有统计学意义（P0.05）。结论 环磷酰胺与泼尼松联合治疗特发性间质性肺炎的效果优于单纯使用泼尼松，可有效改善患者的肺功能指标及预后效果，具有较高的临床推广价值。 　　[关键词]环磷酰胺；泼尼松；特发性间质性肺炎；不良反应；肺功能 　　[中图分类号] R974 [文献标识码] A [文章编号] 1674-4721（2018）4（b）-0127-03 　　Effect analysis of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia 　　TAO Ying-fu 　　Fifth Department of Internal Medicine，Nancheng People′s Hospital in Fuzhou City，Jiangxi Province，Nancheng 344700，China 　　[Abstract]Objective To study the clinical efficacy of Cyclophosphamide and Prednisone in the treatment of idiopathic interstitial pneumonia.Methods Sixty patients with idiopathic interstitial pneumonia admitted in our hospital from February 2015 to September 2016 were selected as the study subjects.They were divided into control group and observation group according to the order of treatment time，with 30 cases in each group.In the control group，Prednisone alone was used，while in the observation group，on the basis of the control group，Cyclophosphamide was added.The total effectiveness rate，incidence of adverse reactions，pulmonary function indicators，sleeping quality score and quality of life score before and after treatment were observed and compared between the two groups.Results In the observation group，the total effectiveness rate was 96.67%，which was higher than that in the control group accounting for 70.00%，the incidence of adverse reactions was 6.67%，which was much lower than that in the control group accounting for 30.00%，the pulmonary function indexes （PEF，MVV，FVC） in the observation group were all higher than those in the control group，the differences were statistically signif