特应性皮炎患者采用他克莫司软膏与二硫化硒洗剂进行治疗临床效果探究.doc

特应性皮炎患者采用他克莫司软膏与二硫化硒洗剂进行治疗临床效果探究 　　[摘要] 目的 探究特应性皮炎患者采用他克莫司软膏与二硫化硒洗剂进行治??的临床效果。方法 随机抽取浦东医院2016年5月―2017年5月收治的100例特应性皮炎患者分为甲组与乙组，各50例，且均用二硫化硒洗剂治疗，甲组同时联合地奈德乳膏治疗，乙组联合他克莫司软膏治疗，对比两组的疗效。结果 ①两组治疗前的临床症状评分、拉色菌数量对比差异无统计学意义（P0.05），治疗后第4周乙组分别是（2.8±1.8）分、（1.0±0.5）个，显著优于甲组的（3.9±2.8）分、（2.0±1.6）个，差异有统计学意义（P0.05）；（3）乙组治疗有效率是90.0%，复发率是11.0%，均优于甲组的70.0%、28.0%，差异有统计学意义（P0.05）。结论 对特应性皮炎患者采取他克莫司软膏与二硫化硒洗剂联合治疗，疗效显著，应用价值高。 　　[关键词] 他克莫司软膏；二硫化硒洗剂；特应性皮炎；临床疗效 　　[中图分类号] R758 [文献标识码] A [文章编号] 1674-0742（2018）01（a）-0146-03 　　Clinical Effect of Tacrolimus Ointment and Selenium Disulfide Lotion in Patients with Atopic Dermatitis 　　WANG Feng1， WANG Ji-yao2， ZHOU Guo-jun3， CHEN Jue4 　　1.Balin Right Banner Maternal and Child Health Family Planning Service Center， Chifeng， Inner Mongolia， 025150 China； 2.Graduate School of Life Science of Fudan University， Shanghai 200438 China； 3.Shanghai Pudong Hospital， Shanghai， 201399 China； 4.Department of Clinical Dermatology， Shanghai Construction Engineering Hospital， Shanghai， 200083 China 　　[Abstract] Objective This paper tries to explore the clinical effect of tacrolimus ointment and selenium disulfide in patients with atopic dermatitis. Methods 100 cases from May 2016 to May 2017 in this hospital were randomly selected and were divided into group A and group B with 50 cases in each group， and were treated with selenium disulfide lotion， group A combined with nedic cream treatment， group B combined with tacrolimus ointment treatment， the efficacy of the two groups were compared. Results ①There was no significant differences in clinical symptom score and the number of T. putida between the two groups before treatment （P0.05）. The fourth week after treatment， the scores were （2.8±1.8） points and （1.0±0.5） in group B， significantly higher than those in group A of （3.9 ± 2.8） points， （2.0±1.6）， the difference was significant（P0.05）；②The risk of adverse reactions in both groups were 10.0%， 16.0%， the difference was not statistically significant（P0.05）. ③The