硫必利联合静灵口服液治疗小儿多发性抽动症临床疗效分析.docVIP

硫必利联合静灵口服液治疗小儿多发性抽动症临床疗效分析 　　[摘要] 目的 研究硫必利联合静灵口服液治疗小儿多发性抽动症的临床疗效。方法 方便选择2015年8月―2017年9月在该院治疗的小儿多发性抽动症62例，根据随机数表法将其分为观察组及对照组，对照组采用硫必利口服治疗，观察组在对照组治疗基础上联用静灵口服液治疗。观察两组患者治疗前后抽动次数、抽动频率及抽动强度评分变化、治疗后的临床疗效及不良反应发生情况。结果 治疗后，观察组总有效率为96.77%，显著高于对照组61.29%（P0.05）。结论 将硫必利及静灵口服液联合应用于多发性抽动症患儿，明显改善了患儿的临床症状，使患儿的临床舒适度提升。 　　[关键词] 硫必利；静灵口服液；小儿多发性抽动症；临床疗效 　　[中图分类号] R749 [文献标识码] A [文章编号] 1674-0742（2017）12（c）-0137-04 　　[Abstract] Objective This paper tries to study the clinical effect of combined treatment of tiapride and Jingling oral liquid on children with tourette disease. Methods 62 children with tourette syndrome treated in this hospital from August 2015 to September 2017 were conveniently selected. Those patients were divided into the control group and the observation group according to random number method. The control group was treated with tiapride oral treatment. The observation group was treated with Jingling oral liquid on the basis of the control group. The changes of twitch frequency， twitch frequency and twitch strength score before and after treatment were observed in both groups. The clinical curative effect and adverse reactions after treatment were observed. Results After treatment， the total effective rate in the observation group was 96.77%， significantly higher than that in the control group of 61.29%（P0.05）. Conclusion The combination of trapride and Jingling oral liquid in children with tourette significantly improve the clinical symptoms of children， so that children’s clinical comfort increases. 　　[Key words] Trapride； Jingling oral liquid； Children with multiple tic disorder； Clinical efficacy 　　多?l性抽动症（Multiple Tics，MT）在临床上被归属为一种慢性神经精神类疾病，多数患者均自孩童时期被发现出现脸部、肢体抽动等异常反应。多发性抽动症的病因非常复杂，且随着人口数量的逐步上升患者数量日益扩大。参考国外相关报道发现，小儿多发性抽动症的发病机制均存在争议，目前普遍认为该病为遗传、心理因素、中枢神经失衡等原因造成，由于对该病发病机制认知的缺失，导致临床至今未研究出可以治愈的方法[1]。据相关统计发现，多发性抽动症主要多发于4～14岁的儿童，且男童的发病数量明显大于女童的发病数量，因该病的临床反应严重，对儿童的生长发育造成影响，临床需要更直接有效的治疗方法来提高临床治疗效果[2]。目前国内外常采用药物控制病情的发展，传统常用药物有硫必利、氟哌啶醇、可乐定等，笔者参考多篇研究发现，单一采用相关药物治疗不仅不良反应