基于PWM思想的深度脑刺激波形成型方案-计算机工程与应用.PDFVIP

Computer Engineering and Applications 计算机工程与应用 2015 ，51（16） 259 基于PWM 思想的深度脑刺激波形成型方案 1 2 1 1 3 陈颖源 ，李会艳 ，王若凡 ，王 江 ，王法光 1 2 1 1 3 CHEN Yingyuan , LI Huiyan , WANG Ruofan , WANG Jiang , WANG Faguang 1.天津大学 电气与自动化工程学院，天津 300072 2.天津职业技术师范大学 自动化与电气工程学院，天津 300222 3.温州市计量技术研究院，浙江 温州 325001 1.School of Electrical Engineering ＆Automation, Tianjin University, Tianjin 300072, China 2.School of Automation ＆Electrical Engineering, Tianjin University of Technology ＆Education, Tianjin 300222, China 3.Wenzhou Institute of Measurement Technology, Wenzhou, Zhejiang 325001, China CHEN Yingyuan, LI Huiyan, WANG Ruofan, et al. Waveform scheme of deep brain stimulation based on principle of PWM. Computer Engineering and Applications, 2015, 51 （16）：259-264. Abstract ：In order to search new Deep Brain Stimulation （DBS ）waveform and simplify the process in setting DBS param - eters, a scheme that modulated the DBS waveform based on the principle of pulse width modulation （PWM ）is proposed. A new DBS waveform is made by Sinusoidal PWM （SPWM ）and a neuronal network model of Parkinson ’s disease is introduced to test the effects of this SPWM DBS. Simulation results show that the effects of this SPWM DBS are identical to that of the periodic pulse DBS and can restore the pathological firing patterns from Parkinsonian state back to normal. The modulated wave amplitude of SPWM, through which DBS energy can be optimized, is the key parameter that influences the effects of SPWM DBS. Key words ：Parkinson ’s disease; Deep Brain Stimulation（DBS ）; Pulse Width Modulation（PWM ）；waveform optimization 摘 要：为寻找新型的深度脑刺激（DBS ）刺激波形和简化DBS 参数设置，提出基于脉宽调制PWM 思想调制DBS 波 形的方案。利用正弦波等效的PWM （SPWM ）形成一种新的DBS 波形，并通过帕金森病网络模型验证了SPWM DBS 的作用效果。仿真结果显示SPWM DBS 与普通的周期性脉冲DBS 作用效果一致，使帕金森病的病态放电恢 复正常。SPWM 调制波幅值是影响SPW