糖代谢异常患者血清C反应蛋白与颈动脉粥样硬化相关性研究.docVIP

糖代谢异常患者血清C反应蛋白与颈动脉粥样硬化相关性研究 　　【摘要】目的探讨糖代谢异常患者血清C反应蛋白（CRP）对颈动脉粥样硬化（AS）的影响。方法选择行糖耐量试验（OGTT）的268例患者，按照OGTT结果分为正常糖耐量组（NGT组）36例、葡萄糖调节异常组（IGR组） 140例、2型糖尿病组（T2DM组） 92例。所有患者进行实验室检查，并检测颈动脉内膜中层厚度（IMT），比较不同糖耐量患者的临床特征及实验室指标。结果NGT组、IGR组、T2DM组在性别、年龄、VLDLC水平上差异无统计学意义（P005），TG、TC、LDLC、CRP水平按NGT组、IGR组、T2DM组依次升高，且差异有统计学意义（P0.05或0.01）；HDLC水平按NGT组、IGR组、T2DM组依次降低，且差异有统计学意义（P0.05或0.01）。结论糖代谢异常患者在积极控制血糖的同时，积极干预炎症反应，对延缓AS的进展，预防远期心脑血管事件的发生有着积极意义。 　　【关键词】糖代谢异常；血清C反应蛋白；颈动脉粥样硬化 　　中图分类号：R543.4 文献标识码：ADOI：10.3969/j.issn2015.03.010 　　Correlation study of serum creactive protein and carotid atherosclerosis of 　　patients with abnormal glucose metabolism 　　TAN Xuexin1，LIN Guocong2 　　（1.Department of Laboratory Medicine，People’s Hospital of Xingbin District，Laibin 546100； 　　2.Department of Laboratory Medicine，People’s Hospital of Luzhai， 　　Luzhai 545600，Guangxi，China） 　　【Abstract】ObjectiveTo investigate influence of serum Creactive protein （CRP） on carotid atherosclerosis（AS） of patients with abnormal glucose metabolism.Methods268 patients receiving oral glucose tolerance （OGTT） were divided into normal glucose tolerance group （NGT group，n=36），impaired glucose regulation group （IGR group，n=140），and diabetes mellitus group（T2DM group，n=92）.All patients received laboratory tests and detection of carotid intima-media thickness （IMT）.Clinical symptoms and laboratory indexes of patients with different glucose tolerances were compared.Results Difference of gender，age and level of VLDLC between the NGT group，the IGR group and the T2DM group was not statistically significant（P0.05）.TG，TC，LDLC and CRP levels successively raised from the NGT group，the IGR group and the T2DM group，and difference was statistically significant（P0.05 or 0.01）.And HDLC level successively decreased from the NGT group，the IGR group and the T2DM group，and difference was statistically significant（P0.05 or 0.01）.ConclusionWhen actively controlling glucose，patients with abnormal glucose metabolism should actively int