葡萄酒中氨基甲酸乙酯污染评估.PDFVIP

中国食品卫生杂志 　　　 　　　　　 — 208 — 2008 年第 20 卷第 3 期 CHINESE JOURNAL OF FOOD HYGIENE 论著 葡萄酒中氨基甲酸乙酯污染评估 周萍萍 　周 　蕊 　赵云峰 　吴永宁 ( 中国疾病预防控制中心营养与食品安全所 ,北京 　100050) 摘 　要 : 目的　对葡萄酒中氨基甲酸乙酯进行污染评估 ,分析其摄入患肺癌的风险 。方法 　采用个体食品研究方 法了解葡萄酒中氨基甲酸乙酯的污染水平 ,结合 2002 年全国营养调查数据 ,剂量反应模型 BMDL 和暴露边界比 ( ) BW Margin of Exposure ,MOE 进行评估 。 结果 　葡萄酒中氨基甲酸乙酯平均暴露量每天 16 ngkg 患肺癌的MOE 为 ( ) BW 188 000 ;氨基甲酸乙酯较高的暴露量 975 百分位 每天 129 ngkg , 患肺癌的MOE 为23 000 。结论 　对我国葡 萄酒中氨基甲酸乙酯的暴露应给予关注 。 关键词 :葡萄酒 ;乌拉坦 ;危险性评估 ;暴露边界比 Contamination Assessment of Dietary Ethyl Carbamate in Wine ZHOU Pingping , ZHOU Rui , ZHAO Yunfeng , WU Yongning (National Institute for Nutrition and Food Safety , Chinese CDC , Beij ing 100050 , China) Abstract : Objective 　The exposure of ethyl carbamate ( EC) in wine was assessed and related to its risk on lung tumor . Method 　The risk of EC exposure was assessed from the contamination level , the consumption of wine in 2002 , the Benchmark dose low limit (BMDL) and the margin of exposure (MOE) . Results 　The mean exposure of EC from wine was 16 ngkg of body weight per day and related MOE was 188 000 when choosing lung tumors as the critical endpoint . High exposure (975 %) of EC was 129 ngkg of body weight per day and related MOE was 23 000. Conclusion 　EC exposure in wine would be of concern in China . Key word : Wine ; Urethane ; Risk Ass