葛根素葡萄糖注射液对椎基底动脉供血不足患者脑血流动力学和血液流变学影响.docVIP

葛根素葡萄糖注射液对椎基底动脉供血不足患者脑血流动力学和血液流变学影响 　　 摘要:目的 观察葛根素葡萄糖注射液对椎基底动脉供血不足患者脑血流动力学、血液流变学的影响。方法 椎基底动脉供血不足患者240例，随机分成两组。治疗组用葛根素葡萄糖注射液250 mL/d静脉输注；对照组用复方丹参注射液20 mL/d 静脉输注。治疗前后分别对两组患者进行脑血流动力学、血液流变学检测。结果 治疗组总有效率为93.3%，对照组为70.0%(P0.01)；葛根素葡萄糖注射液与复方丹参注射液均可降低椎基底动脉供血不足患者的血液黏稠度；治疗组在改善脑血流速度方面优于对照组(P0.05)。结论 葛根素葡萄糖注射液可以改善椎基底动脉供血不足患者脑血流动力学，降低血液黏稠度，作用优于复方丹参注射液。 　　 关键词:椎基底动脉供血不足；葛根素葡萄糖注射液；复方丹参注射液；脑血流动力学；血液流变学 　　 中图分类号：R743 R289.5 文献标识码：C 文章编号：1672-1349（2012）01-0058-02 　　The Influence of Puerarin Glucose Injection on Cerebral Hemodynamics and Hemorheology in Vertebrobasilar Insufficiency 　　Sun Huiru,Yang Qingyou // Wuxi Affiliated Hospital,Nanjing University of Traditional Chinese Medicine (Wuxi 214001) 　　 Abstract：Objective To observe the effects of puerarin glucose injection on cerebral haemodynamics and hemorheology in patients (pts) with vertebrobasilar insufficiency.Methods Two hundreds and forty pts with vertebrobasilar insufficiency were randomly divided into two groups:Treatment group (n=120) treated with puerarin glucose injection,and control group (n=120) treated with compound Danshen injection.Before and after treatment,cerebral hemodynamics and hemorheology were detected.Results The total effective rate was 93.3% in treatment group and 70% in control group（P＜0.01）.Puerarin glucose injection and compound Danshen injection decreased blood viscosity.The speed flow velocity of brain in treatment group was better than that in control group（P＜0.05）.Conclusion Puerarin glucose injection could improve cerebral haemodynamics and decrease blood viscosity,which was more effective than compound Danshen injection. 　　 Key words:vertebrobasilar insufficiency;puerarin glucose injection;compound Danshen injection;cerebral haemodynamics;hemorheology 　　 　　 椎基底动脉供血不足(vertebrobasilar ischemia，VBI)是由各种原因引起的椎基底动脉狭窄、痉挛或闭塞导致脑干、小脑或枕叶皮层短暂性缺血，临床主要表现为与体位变化有关的眩晕。 　　1 资料与方法 　　1.1 一般资料 240例均为在无锡市中医医院的住院患者，经颅多普勒超声扫描(TCD)确诊为椎基底动脉供血不足，符合国家中医药管理局颁布的《中医病证诊断疗效标准》关于眩晕的诊断［1］。同时排除颅内占位病变、急性脑卒中、内耳眩晕等疾病。男122例