芳香化酶抑制剂治疗妇科内分泌疾病效果分析.docVIP

芳香化酶抑制剂治疗妇科内分泌疾病效果分析 　　[摘要] 目的 探讨芳香化酶抑制剂在妇科内分泌疾病治疗中的应用价值。 方法 选取2010年8月～2012年8月在本院治疗的妇科内分泌患者90例，分别给予依西美坦（n=36）、阿那曲唑（n=28）和来曲唑（n=26）治疗，观察芳香化酶抑制剂的疗效、3组患者血清雌二醇（E2）抑制情况及不良反应发生情况。 结果 依西美坦组、阿那曲唑组和来曲唑组的治疗总有效率分别为94.44%、92.86%和92.31%，差异无统计学意义（P0.05）。治疗后3组患者血清E2水平明显下降，与治疗前比较差异有统计学意义（P0.05）；依西美坦组患者的血清E2抑制率及有效抑制率优于其他两组（P0.05）。3组均未出现严重不良反应；在体重增加上来曲唑组尤为显著（P0.05）。 结论 芳香化酶抑制剂可有效治疗妇科内分泌疾病，且药物耐受性好。 　　[关键词] 芳香化酶抑制剂；内分泌疾病；血清雌二醇；应用价值 　　[中图分类号] R711 [文献标识码] A [文章编号] 1674-4721（2014）09（a）-0075-03 　　Effect analysis of aromatase inhibitor treatment of gynecologic endocrine diseases 　　DENG Jin-feng 　　Department of Obstetrics And Gynecology，the Second Hospital of Nanchang City，Nanchang 330002，China 　　[Abstract] Objective To explore the application value of aromatase inhibitor in gynecologic endocrine diseases. Methods 90 patients with gynecologic endocrine diseases treated in our hospital from August 2010 to August 2012 were selected and respectively for exemestane （n=36），anastrozole （n=28） and letrozole （n=26） treatment，the curative effect of aromatase inhibitors，three groups of patients with serum estradiol inhibition condition and adverse reactions occur were observed. Results The total effective rate was 94.44%，92.86% and 92.31% respectively in exemestane group，anastrozole group and letrozole group，there was no statistically significant difference （P0.05）.The serum E2 level in three groups of patients were significantly decreased after treatment，the difference was statistically significant compared with before treatment （P0.05）.The serum E2 inhibition rate and efficient inhibition in exemestane group patients were better than the other two groups （P0.05）.No serious adverse reaction occurred in 3 groups，on weight gain letrozole group was significant （P0.05）. Conclusion Aromatase inhibitors can effectively treat gynecological endocrine diseases，and drug tolerance. 　　[Key words] Aromatase inhibitors；Endocrine diseases；Serum estradiol；Application value 　　妇科内分泌疾病极为常见，月经不调、痛经、子宫内膜异位等均属此