肠炎宁胶囊联合美沙拉嗪治疗溃疡性结肠炎30例临床疗效观察.docVIP

肠炎宁胶囊联合美沙拉嗪治疗溃疡性结肠炎30例临床疗效观察 　　【摘要】 目的 ?u价肠炎宁胶囊联合美沙拉嗪治疗溃疡性结肠炎（UC）的有效性和安全性。方法 60例溃疡性结肠炎患者， 按照随机数字表法分为试验组和对照组， 各30例。对照组给予美沙拉嗪肠溶片口服治疗， 试验组给予肠炎宁胶囊联合美沙拉嗪肠溶片口服治疗。连续用药8周后， 观察两组患者临床症状体征评分、Mayo活动指数评分和安全性指标。结果 试验组患者治疗总有效率为93.33%， 明显高于对照组的73.33%， 差异具有统计学意义（χ2=4.320， P=0.0230.05）；两组治疗后Mayo活动指数评分均低于治疗前， 差异具有统计学意义（P0.05） ， 治疗后试验组Mayo活动指数评分明显低于对照组， 差异具有统计学意义（P0.05）；试验组Mayo活动指数评分下降值明显大于对照组， 差异具有统计学意义（P0.05）。结论 肠炎宁胶囊联合美沙拉嗪可以明显改善溃疡性结肠炎患者临床症状体征评分和Mayo活动指数评分， 且肠炎宁胶囊临床应用安全性好， 临床应用价值高， 值得在临床推广使用。 　　【关键词】 溃疡性结肠炎；肠炎宁胶囊；美沙拉嗪；临床效果 　　DOI：10.14163/j.cnki.11-5547/r.2017.32.052 　　Observation on clinical efficacy of Changyanning capsule combined with mesalazine in the treatment of 30 cases of ulcerative colitis ZHAO Qing-hua， LI Yan， ZHOU Yong-zhi， et al. Department of Hepatobiliary and Spleen， Kaifeng City Traditional Chinese Medicine Hospital， Kaifeng 475001， China 　　【Abstract】 Objective To evaluate the effectiveness and safety of Changyanning capsule combined with mesalazine in the treatment of 30 cases of ulcerative colitis （UC）. Methods A total of 60 ulcerative colitis patients were divided by random number table method into experimental group and control group， with 30 cases in each group. The control group was treated with oral administration of mesalazine， and the experimental group was treated with oral administration of Changyanning capsule and mesalazine. After 8 weeks of continuous treatment， observation were made on clinical symptom score， Mayo activity index score and safety index in two groups. Results The experimental group had obviously higher total treatment effective rate as 93.33% than 73.33% in the control group， and the difference was statistically significant （χ2=4.320， P=0.0230.05）. After treatment， both groups had lower Mayo activity index score than before treatment， and the difference was statistically significant （P0.05）. After treatment， the experimental group had obviously lower Mayo activity index score than the control group， and the difference was statistica