胆管癌患者血清CEACA199CA242联合检测临床意义.docVIP

胆管癌患者血清CEACA199CA242联合检测临床意义 　　[摘要] 目的：探讨胆管癌患者血清CEA、CA19-9、CA242的检测对其诊断的临床应用价值。方法：采用化学发光免疫法及放射免疫分析法对148例胆管癌患者血清CEA、CA19-9、CA242进行检测。结果：CEA、CA19-9、CA242敏感性分别为52.70％，82.43％，63.51％，联合检测敏感性为89.89％，较单独检测明显提高。CA19-9在术后2周明显下降，对判断胆管癌的预后可能有重要意义。结论：三种标志物联合检测可明显提高胆管癌的检出率, 降低漏检率；CA19-9在监测胆管癌术后复发中可能具有较大的临床价值。 　　[关键词] 胆管癌；CEA；CA19-9；CA242 　　[中图分类号] R446 [文献标识码]B [文章编号]1673-7210（2008）07（a）-096-02 　　 　　Study of relationship between cholangiocarcinoma with CEA,CA19-9 and CA242 in bile and blood 　　CHEN Jin-long1,YI Shi-jian1, HE De2,ZHONG De-wu3,ZHAO Zhen-wei1,XIANG Hua-guo1 　　(1.Department of Surgery,Fuyong Hospital,Shenzhen 518103,China；2.Department of General Surgery,Bao-an Peoples Hospital,Shenzhen 518101,China；3.The second Xiangya Hospital,Central South University,Changsha 410008,China) 　　[Abstract] Objective:To investigate the clinical value of CEA,CA19-9 and CA242 in thediagnosis of cholangiocarcinoma patients.Methods:CEA,CA19-9,CA242 in 148 cases were detected in Chemiluminescent immunoassay and radioimmunoassay .Results:The sensitivity rates of using single positive diagnostic indicator of CEA，CA19-9，CA242 to cholangiocarcinoma were 52.70％，82.43％ and 63.51％, respectively, in combined detectionfor three tumor markers, the sensitivity rates increased to 89.89%, obviously higher than in single delection. CA19-9 decreased sharply two weeks later after operation, it indicated that CA19-9 was an important marker on prognosis of cholangiocarcinoma.Conclusion:In combined detection for the three tumor markers would obviously increase cholangiocarcinoma diagnosis rates and decrease missed diagnosis rates. It might have an important clinical value of CA19-9 on monitoring postoperative recurrent cholangiocarcinoma. 　　[Key words] Cholangiocarcinoma；CEA；CA19-9；CA242 　　 　　胆管癌恶性程度高、预后差。实现对胆管癌的早期诊断以及根据其预后情况开展有效的综合治疗是提高胆管癌患者生存率的重要手段。检测血清肿瘤标志物是一种有效的无创检查方法，联合检测两种以上肿瘤标志物可以弥补单个肿瘤标志物的某些局限性，提高诊断的敏感性和特异性。癌胚抗原(carcinoembryonic antigen, CEA),癌抗原19-9(cancer antigen 19-9，CA19-9)和癌抗原242(cance