芪参益气滴丸对ACS患者冠脉介入治疗后无复流疗效观察.docVIP

芪参益气滴丸对ACS患者冠脉介入治疗后无复流疗效观察 　　摘要：目的 观察芪参益气滴丸对急性冠脉综合征（acute coronary syndrome，ACS）患者行经皮冠脉介入治疗（percutaneous coronary intervention， PCI）术后无复流的影响。方法 84例于2014 年 5 月～2015 年 5 月在天津市武清区中医医院行PCI治疗的患者随机分为芪参益气滴丸+常规治疗组（实验组n=42）及常规治疗组（对照组n=42），对照组予PCI术后西药常规治疗，实验组在对照组基础上给予芪参益气滴丸，分别于PCI 术前、术后根据 TIMI 血流分级法评估冠状动脉血流，术前及术后1d、4w超声心动图观察左室射血分数（LVEF）变化，术后30min及24h记录心电图，观察ST段抬高最显著导联ST段回落的情况。结果 术后实验组TIMI 3级血流者显著多于对照组（P0.05）；左心室射血分数 [（56.3±4.3）%]较对照组[（48.3±7.3）%]明显提高（P0.05）；结论 本研究表明芪参益气滴丸明显促进PCI术后心肌血流，防止无复流的发生，促进ACS患者心功能恢复。 　　关键词：急性冠脉综合征；PCI；无复流；芪参益气滴丸 　　Abstract：Objective To investigate the effects of Qishen Yiqi drop pil （QYDP）on the non-reflow phenomenon of patients with acute coronary syndrome （ACS）after percutaneous coronary intervention （PCI）.Methods 84cases of ACS patients after PCI hospitalized in Tianjin WuQing Traditional Chinese Medicine Hospital from May，2014 to May，2015 were divided into two groups randomly.The control group （n=42）was treated by routine treatment，and treatment group（n=42） was treated by QYDP on the basis of routine treatment.The coronary blood flow was observed by TIMI flow grade before and after PCI and left ventricular ejection fraction（LVEF） by ultrasonic cardiogram 1 day and 4 weeks respectively after PCI.Electrocardiography was performed to analyse ST segment resolution 30 minutes and 24 hours after PCI.Results The ratio of blood flow reaching to TIMl3 was significantly higher in treatment group as compared to control group（P0.05）.The LVEF was higher in treatment group[（56.3±4.3）%]than that in control group[（48.3±7.3）%]（P0.05）.The ratio of ST segment reduction over 50%in treatment group was higher than that in control group 30 minutes after PCI（P0.05）and the difference was not significant between the two groups 24 hours after PCI.Conclusion QYDP could improve coronary blood flow after PCI and prevent the occurrence of non-reflow phenomenon，so as to improve cardiovascular function of ACS patients. 　　Key words：ACS；PCI；Non-reflow phenomenon；Qishen Yiqi dro