胸腺肽联合化疗对老年胃癌血清Th1Th2细胞因子效果影响分析.docVIP

胸腺肽联合化疗对老年胃癌血清Th1Th2细胞因子效果影响分析 　　[摘要] 目的 对胃癌老年患者行胸腺肽和化疗联合治疗的血清辅助性T细胞1（Helper T cells 1，Th1）、Th2细胞因子的效果进行分析。 方法 便利选取2015年8月―2016年8月该院收治的胃癌60例老年患者临床资料加以分析，依据治疗时所用不同方案分成两组，均为30例，对照组行单纯化疗医治，观察组联合胸腺肽医治，对比两组血清Th1、Th2细胞因子与基质金属蛋白酶（Matrix metallo protein-9，MMP-9）、MMP-2及T细胞亚群水平。结果 观察组血清Th1、Th2细胞因子水平均比对照组优，且MMP-9、MMP-2水平（49.20±7.16）ng/mL、（43.25±6.70）ng/mL均比对照组优（P0.05）。结论 胃癌老年患者行胸腺肽和化疗联合治疗能够改善血清Th1、Th2细胞因子与MMP-9、MMP-2水平，且增强患者免疫功能。 　　[关键词] 胃癌；化疗；胸腺肽；细胞因子；免疫功能 　　[中图分类号] R735.2 [文献标识码] A [文章编号] 1674-0742（2017）02（b）-0034-03 　　[Abstract] Objective To analyze the effect of thymic peptide and chemotherapy on the serum Th1 and Th2 cell factor of senile gastric cancer. Methods 60 cases of senile patients admitted and treated in our hospital from August 2015 to August 2016 were selected and divided into two groups according to the different plans with 30 cases in each， the control group were treated with simple chemotherapy， while the observation group were treated with thymic peptide and chemotherapy， and the serum Th1 and Th2 cell factors， Matrix metallo protein-9，MMP-9， MMP-2 and T cell subgroup level were compared. Results The serum Th1 and Th2 cell factors in the observation group were better than those in the control group， and the MMP-9 and MMP-2 levels in the observation group were respectively（49.20±7.16）ng/mL and（43.25±6.70）ng/mL， which were better than those in the control group（P0.05）. Conclusion The thymic peptide and chemotherapy on the serum Th1 and Th2 cell factors of senile gastric cancer can improve the serum Th1 and Th2 cell factors， MMP-9 and MMP-2 levels and enhance the immune function of patients. 　　[Key words] Gastric cancer； Chemotherapy； Thymic peptide； Cell factor； Immune function 　　胃癌?儆谖覆孔畛＜?肿瘤，并发症多发，且伴随现代化进程加快，此类疾病发病率不断上升，且逐渐呈年轻化趋势，对患者生命安全造成严重威胁，需引起临床医师和患者高为疾病治疗提度重视[1-3]。对于老年胃癌，临床一般行化疗治疗，但单纯治疗效果欠佳，为提高临床治疗效果，改善患者预后，并供重要参考，该研究针对该院2015年8月―2016年8月收治的胃癌60例老年患者分别行单纯化疗和联合胸腺肽医治效果加以对比分析，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　便利选取2015年8月―2016年8月该院收治的胃癌60例老年患者临床资料予以分析，该