脑出血合并神经源性肺水肿相关危险因素研究.docVIP

脑出血合并神经源性肺水肿相关危险因素研究 　　[摘要] 目的：研究脑出血合并神经源性肺水肿的危险因素。方法：选择我院2006年10月~2010年12月收治的脑出血合并神经源性肺水肿患者60例为研究组，选择同期住院单纯脑出血患者60例为对照组，比较分析两组患者心率（HR）、血清C反应蛋白（hs-CRP）、脑钠肽（BNP）、氧合指数、组织因子（TF）等指标对是否合并神经源性肺水肿的影响。结果：两组性别、年龄、GCS评分、hs-CRP比较，差异均无统计学意义（均P0.05），研究组患者HR、BNP、TF明显高于对照组，氧合指数明显低于对照组，两组比较差异均有统计学意义（均P0.05），多因素回归分析显示心率增快，BNP、TF增高及氧合指数降低是脑出血合并神经源性肺水肿的独立危险因素。结论：HR、BNP、TF、氧合指数是脑出血合并神经源性肺水肿独立影响因素，临床对于该指标出现变化的患者，应加强监测，预防意外发生。 　　[关键词] 脑出血；神经源性肺水肿；危险因素 　　[中图分类号] R743.34 [文献标识码] Ａ [文章编号] 1673-7210（2011）11（a）-052-02 　　 　　Study on risk factors of cerebral hemorrhage combined with neurogenic pulmonary edema 　　CHEN Liyin 　　Department of ICU, Traditional Chinese Medicine of Xiamen City, Fujian Province, Xiamen 361000, China 　　[Abstract ] Objective: To study the risk factors of cerebral hemorrhage combined with neurogenic pulmonary edema. Methods: 60 patients of cerebral hemorrhage combined with neurogenic pulmonary edema in our hospital from October 2006 to December 2010 were selected as study group, 60 patients with cerebral hemorrhage over the same period were selected as the control group, the effect of heart rate, serum C-reactive protein, brain natriuretic peptide, oxygenation index and tissue factors to neurogenic pulmonary edema were analyzed. Results: There was no significant difference of gender, age, GCS score, hs-CRP between the two groups (all P0.05); HR, BNP, TF of study group was significantly higher than those of the control group, oxygenation index was significantly lower than that of the control group, the differences were statistically significant (all P0.05), multivariate analysis showed that faster heart rate, increased BNP, TF, decreased oxygenation index were independent risk factors of neurogenic pulmonary edema in cerebral hemorrhage patients. Conclusion: HR, BNP, TF and oxygenation index are independent factors of neurogenic pulmonary edema in cerebral hemorrhage patients, we should strengthen the monitoring in patients with changese of those indexs in clinical