脑心通胶囊对急性脑梗死患者血清VEGFMDA水平影响研究.docVIP

脑心通胶囊对急性脑梗死患者血清VEGFMDA水平影响研究 　　 摘要：目的 探讨急性脑梗死患者血清血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)和自由基丙二醛（MDA）含量在不同时间段变化及脑心通胶囊的治疗影响。方法 选择60例脑梗死患者，随机分为治疗组和对照组，各30例，并设立健康组60名。治疗组给予脑心通胶囊口服。采用双抗体夹心ELISA及比色法动态测定法于1 d、3 d、7 d、14 d检测患者血清VEGF及MDA含量，治疗前及治疗后14 d进行神经功能评分。结果 脑梗死组各时间点血清VEGF的水平明显高于健康组(P0.05)。结论 急性脑梗死后血清VEGF浓度明显增高，VEGF和MDA共同参与脑梗死急性期血管病理损伤过程，脑心通胶囊干预治疗可增加VEGF含量。VEGF可作为评估急性脑梗死患者病情轻重和预后的客观指标。 　　 关键词：急性脑梗死；血管内皮细胞生长因子；丙二醛；脑心通胶囊 　　 中图分类号：R743.3 R289.5 文献标识码：B 文章编号：1672-1349（2012）01-0054-03 　　The Influence of Naoxintong Capsule on Serum VEGF and MDA Levels in Acute Cerebral Infarction 　　He Jianming,Li Yurong,Wei Yingxiu,et alDepartment of Neurology,Liuzhou Municipal Liutie Central Hospital,Guangxi (Liuzhou 545007) 　　 Abstract：Objective To investigate effect of Naoxintong capsule on serum vascular endothelial growth factor (VEGF) and malondialdehyde (MDA) in patients (pts) with acute cerebral infarction(ACI). Methods Sixty pats with cerebral infarction were randomly divided into treatment group (n=30) treated with Naoxintong capsule,and control group (n=30).Serum VEGF levels were detected by double-antibody sandwich ELISA at 24 h,3 d,7 d,14 d.Serum MDA levels were detected by spectrophotometer at the same time.Neurological function score were studied before and after treatment for 14 d.Results The levels of VEGF in pts with ACI were significantly higher than that in normal group (P0.05).Conclusion The levels of serum VEGF were significantly increased after ACI.VEGF and MDA may take part in cerebral vascular pathological damage together.VEGF levels were significantly increased after treatment of Naoxintong capsule.VEGF could be as an important reference index to evaluate the condition and prognosis of ACI. 　　 Key words:acute cerebral infarction;vascular endothelial growth factor;malondialdehyde;Naoxintong capsule 　　 　　 血管内皮生长因子(vascular endothelial growth factor,VEGF)是由两个亚基间通过二硫键连接形成的同源二聚体糖蛋白，其具有促进血管生成、增加血管渗透性、保护神经细胞、促进内皮细胞增殖等四大生物学特性，在血管发生和形成过程中起着重要的调控作用。有研究表明，V