血清内源性硫化氢在支气管哮喘患儿中表达及与呼吸功能相关性分析.docVIP

血清内源性硫化氢在支气管哮喘患儿中表达及与呼吸功能相关性分析 　　[摘要] 目的 探讨气体信号分子内源性硫化氢在支气管哮喘患儿血清中的表达情况及其与呼吸功能的相关性。 方法 选取2013年12月～2014年12月本院收治的50例支气管哮喘急性发作期患儿作为急性发作组，50例支气管哮喘缓解期患儿作为缓解组，选取同期的50例健康小儿作为对照组，采用敏感硫电极法检测血清硫化氢表达水平，采用肺功能检测仪检测各组呼吸功能，比较3组的内源性硫化氢表达水平及用力肺活量（FVC）、第一秒最大呼气率（FEV1%）、最大呼气中期流速（MMEF）等指标，分析急性发作期患儿FVC、FEV1%、MMEF与内源性硫化氢表达水平的相关性。 结果 急性发作组和缓解组的血清内源性硫化氢水平显著低于对照组，急性发作组的血清内源性硫化氢水平显著低于缓解组，差异有统计学意义（P0.05）。急性发作组和缓解组的FVC、FEV1%及MMEF水平显著低于对照组，急性发作组的FVC、FEV1%及MMEF水平低于缓解组，差异具有统计学意义（P0.05）。急性发作组内源性硫化氢表达水平同用力肺活量、第一秒最大呼气率、最大呼气中期流速呈现正相关。 结论 内源性硫化氢在支气管哮喘患儿中的表达水平降低，并且和呼吸功能相关，检测内源性硫化氢水平对于预测肺功能具有一定的临床意义。 　　[关键词] 内源性硫化氢；支气管哮喘；小儿；用力肺活量；第一秒最大呼气率；最大呼气中期流速 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-4721（2015）09（b）-0085-03 　　Expreesion of endogenous hydrogen sulfide in serum in children with bronchial asthma and its correlativity with respiratory function 　　TANG Dan1 XIA Wan-min2 　　1.Department of Pediatrics，the Second Clinical College of Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China；2.Department of Respiration，Women and Children′s Central Hospital of Chengdu City，Chengdu 610017，China 　　[Abstract] Objective To explore expressive level of endogenous hydrogen sulfide （H2S） in serum in children with bronchial asthma and its correlativity with respiratory function. Methods 50 children with bronchial asthma in acute attack stage from December 2013 to December 2014 in our hospital was selected as the acute attack group，50 children with bronchial asthma in remission stage were selected as the remission group and 50 cases of healthy children were selected as the control group during the same period.Endogenous H2S was detected with sensitive sulphur electrode and respiratory function was detected with lung function diagnostic system in every groups.The expression level of endogenous H2S，the index of forced vital capacity（FVC），forced expiratory volume in 1 second （FEV1%），maximal mid-expiratory flow （MMEF） among three groups was compared respectiveiy，and relativity of H2S with FVC，FEV1% and MMEF