西帕依固龈液防治口腔黏膜急性放射损伤疗效观察.docVIP

西帕依固龈液防治口腔黏膜急性放射损伤疗效观察 　　【摘要】 目的 探讨西帕依固龈液防治放疗患者口腔黏膜急性放射损伤的疗效。方法 将 80例鼻咽癌、口腔癌术后放疗出现口腔黏膜急性放射损伤的患者随机分成两组,以西帕依固龈液含漱治疗的患者为治疗组,洗必泰液含漱治疗的患者作为对照组,按 WHO 放射性口腔黏膜反应标准记录患者口腔黏膜放射损伤的程度。结果 西帕依固龈液治疗40例,出现Ⅰ、Ⅱ、Ⅲ、Ⅳ级口腔黏膜炎分别为 17、14、4、5例; 对照组 40例,出现Ⅰ、Ⅱ、Ⅲ、Ⅳ级口腔黏膜炎分别为2、5、20、13例; 两组比较差异具有显著性(P0.05)。结论 西帕依固龈液防治口腔黏膜急性放射损伤具有良好的疗效。 　　【关键词】 西帕依固龈液;口腔黏膜急性放射损伤 　　 　　Therapeutic effect observation ofxipayi mouthrinse to prevent acute oral mucosa radiation injury 　　 　　WANG Yue-ping,YOU Yun-hua,LIANG Jun,et al.Department ofOralandMaxillofacial Surgery,Department of Radiotherapy ,TheFifthAffiliatedHospital,Sun Yet-sen University,Zhuhai 519000,China 　　 　　【Abstract】 Objective To investigate the effect of xipayi mouth rinse in treating acute oral mucosa radiation injury of radiotherapy patients.Methods 80 patients of nasopharyngeal carcinoma(NPC)and oral carcinoma postoperation radiotherapy with acute oral mucosa radiation injury were randomlydividedintotwogroups.Patients in the therapia group were treated by xipayi mouthrinse,Patientsinthecontrolgroup were treated by chlorhexidine.Theseverity of oral mucosa radiation injury wasassessedaccording to WHO Scoring of Oral Mucositis.Results Cases of the experimental group by xipayimouthrinse were 40,cases of grade Ⅰ,Ⅱ,Ⅲ and Ⅳ oral mucosa radiation injury were 17,14,4 and 5 respectively.Whereas in the control group,cases of the control group were 40,cases ofgradeⅠ,Ⅱ,Ⅲ and Ⅳ oral mucosa radiation injury were 2,5,20 and 13 respectively.The difference bwteen two groups was statistically significant(P0.05).Conclusion The effect of xipayi mouthrinse in treating acute oral mucosa radiation injury is satisfactory. 　　【Key words】 Xipayi mouth rinse; Acute oral mucosa radiation injury 　　 　　作者单位:519000珠海, 　　中山大学附属第五医院口腔颌面外科(汪跃平 游云华 梁军), 放疗科(王思阳) 　　 　　口腔黏膜急性放射性损伤是头颈部肿瘤放疗患者常见的并发症[1,2]。放射性口腔黏膜炎表现为:口咽黏膜充血、水肿、糜烂、溃疡、白膜形成,甚至疼痛、进食困难,严重影响患者的治疗进程和生活质量,并影响放疗计划的完成。目前临床针对口腔黏膜放射损伤多采用局部止痛含漱、雾化吸入及喷剂等治疗,严重者全身静脉给药对症处理,疗效均不满意。西帕依固龈液是由维吾尔族习用单味药材没食子经提取精制而成的漱口液,属部颁标准#8226;维吾尔药分册收