血清白介素―17在下呼吸道感染诊断及预后判断中应用.docVIP

血清白介素―17在下呼吸道感染诊断及预后判断中应用 　　[摘要] 目的 探讨血清白介素-17（IL-17）在下呼吸道感染诊断及预后判断中的价值。方法 选取140例下呼吸道感染患者为研究对象，依据是否发生细菌性感染将其分为感染组（n=78）和非感染组（n=62），依据急性生理及慢性健康状况评分将感染组患者分为预后良好组及预后不良组。选取50例健康者为对照组。采用ELISA法检测各组血清IL-17水平。 结果 （1）与对照组相比较，非感染组和感染组患者血清IL-17水平显著升高（P0.05）；感染组患者血清IL-17水平显著高于非感染组（P0.05）。（2）入院1d和7d，预后良好组血清IL-17水平均显著低于预后不良组（P0.05）；相关性分析结果显示，血清IL-17水平与APACHE Ⅱ评分存在明显正相关（r=0.381， P=0.002）。（3）血清IL-17对下呼吸道感染诊断的灵敏度和特异度分别为74.4%、95.7%；对预后判断的灵敏度和特异度分别71.1%、97.4%。 结论 血清IL-17在下呼吸道细菌性感染的诊断及预后判断中具有良好的指导意义。 　　[关键词] 下呼吸道；细菌感染；白介素-17；诊断；预后 　　[中图分类号] R446.5 [文献标识码] A [文章编号] 2095-0616（2017）07-125-03 　　Application of serum interleukin -17 in the diagnosis and prognosis of lower respiratory tract infection 　　REN Chunna YU Qi ZHAO Yue ZHANG Yang 　　Clinical Laboratory， the Second Affiliated Hospital of Mudanjiang Medical University， Heilongjiang， Mudanjiang 157000， China 　　[Abstract] Objective To evaluate the value of interleukin-17 （IL-17） in the diagnosis and prognosis of lower respiratory tract infection. Methods 140 cases with lower respiratory tract infection were divided into infection group（n=78） and non-infection group（n=62）on the basis of bacterial infection. Infection group was divided into good prognosis group and poor prognosis group on the basis of APACHEⅡ. 50 cases of healthy was selected as control group. IL-17 was detected by ELISA. Results （1） Compared with control group，IL-17 levels of infection group and non-infection group were higher（P0.05）； ，IL-17 level of infection group was higher than the non-infection group （P0.05）. （2） On 1 day and 7 day after admission，IL-17 levels of good prognosis group were lower than poor prognosis group （P0.05）； Correlation analysis showed， there was a positive correlation between serum IL-17 level and APACHE score of II（r=0.381， P=0.002）. （3）The sensitivity and specificity of serum IL-17 in the diagnosisof lower respiratory tract infection were 74.4% and 95.7%；The sensitivity and specificity in the prognosis of lower respiratory tract infecti