血清间皮素和血管内皮生长因子C对卵巢癌诊断价值.docVIP

血清间皮素和血管内皮生长因子C对卵巢癌诊断价值 　　摘要：目的 探讨血清间皮素和血管内皮生长因子C（VEGF-C）对卵巢癌的诊断价值。方法 比较卵巢癌组（108例）、卵巢良性疾病组（126例）和正常对照组（200例）血清间皮素和VEGF-C水平，以受试者工作特征（ROC）曲线和Logistic回归-ROC曲线分别评估单一和联合指标对卵巢癌的诊断价值。结果 血清间皮素和VEGF-C水平在卵巢癌组均显著高于卵巢良性疾病组和健康对照组（P0.05）。血清间皮素和VEGF-C的ROC曲线下面积（AUC）分别为0.88[95%参考区间（CI），0.80～0.93]和0.85（95%CI，0.81～0.92）。联合检测血清间皮素和VEGF-C的AUC为0.91（95%CI，0.88～0.95），灵敏度和特异性分别为86.1%和89.4%。结论 联合检测血清间皮素和VEGF-C有助于卵巢癌的鉴别诊断。 　　关键词：卵巢癌；间皮素；血管内皮生长因子C 　　Diagnostic Value of Serum Mesothelin and VEGF-C for Ovarian Cancer 　　WANG Qin1，TIAN Gang2 　　（1. Department of Obsterics and Gynecology， The Affiliated Hospital of Southwest Medical University，Luzhou 646000，Sichuan，China； 　　2. Department of Clinical Laboratory of Medicine， The Affiliated Hospital of Southwest Medical University，Luzhou 646000，Sichuan，China） 　　Abstract：Objective To investigate the diagnostic significance of serum mesothelin and vascular endothelial growth factor-C （VEGF-C） for ovarian cancer. Methods Serum levels of mesothelin and VEGF-C were compared among the patients with ovarian cancer （n=108）， patients with ovarian benign diseases （n=126） and the healthy controls （n=200）. The methods of the receiver operating characteristic （ROC） curve and logistic regression analysis-ROC curve were used to evaluate the diagnostic values of serum mesothelin and VEGF-C individually and in combination. Results Serum levels of mesothelin and VEGF-C in the ovarian cancer group were significantly higher than those in the ovarian benign diseases group and the healthy controls （P0.05）. The area under the ROC （AUC） of serum mesothelin and VEGF-C was 0.88[95% confidence intervals （CI）， 0.80～0.93]， and 0.85 （95%CI， 0.81～0.92）， respectively. The AUC of combined serum biomarkers of mesothelin and VEGF-C was 0.91（95%CI，0.88～0.95） with 86.1% of sensitivity and 89.4% of specificity. Conclusion The combined measurement of serum mesothelin and VEGF-C is helpful for the diagnosis of ovarian cancer. 　　Key words：Ovarian cancer； Mesothelin； Vascular endothel