血清游离脂肪酸血栓调节蛋白在妊娠期高血压疾病患者中表达及其相关性分析.docVIP

血清游离脂肪酸血栓调节蛋白在妊娠期高血压疾病患者中表达及其相关性分析 　　[摘要] 目的 探讨游离脂肪酸和血栓调节蛋白在妊娠期高血压疾病患者中的表达及其相关性。 方法 选择本院2013年1月～2014年11月收治的100例孕妇作为研究对象，按照有无妊娠期高血压疾病分为观察组（妊娠期高血压）和对照组（正常妊娠孕妇），各50例。两组均采用酶联免疫吸附试验法检测血清中的游离脂肪酸和血栓调节蛋白水平。比较两组的血清游离脂肪酸与血栓调节蛋白水平，对血清游离脂肪酸与血栓调节蛋白的相关性进行分析。 结果 观察组的血清游离脂肪酸与血栓调节蛋白水平显著高于对照组，差异有统计学意义（P0.05）。观察组不同孕周的血清游离脂肪酸与血栓调节蛋白水平显著高于对照组，差异有统计学意义（P0.05）。两组的血清游离脂肪酸与血栓调节蛋白水平随着孕周的增加也逐渐增高，差异有统计学意义（P0.05）。血栓调节蛋白与血清游离脂肪酸水平呈正相关（r=0.6604，P0.05）。 结论 妊娠期高血压疾病的发病与游离脂肪酸浓度偏高及血栓调节蛋白水平有关，血栓调节蛋白水平与游离脂肪酸浓度呈正相关。 　　[关键词] 游离脂肪酸；血栓调节蛋白；妊娠期；酶联免疫分析法 　　[中图分类号] R714.24+6 [文献标识码] A [文章编号] 1674-4721（2016）05（b）-0069-03 　　[Abstract] Objective To explore the expression and correlation on serum free fatty acid （FFA） and thrombomodulin （TM） in patients with hypertensive disorder complicating pregnancy. Methods 100 pregnant women in our hospital from January 2013 to November 2014 were selected and divided into the observation group （hypertensive disorder complicating pregnancy） and the control group （ healthy pregnant women），50 cases in each group.The level of serum FFA and TM in the two groups were detected by ELISA and then compared，the correlation between serum FFA and TM was analyzed. Results The level of serum FFA and TM in the observation group was higher than that in the control group，with significant difference （P0.05）.The level of serum FFA and TM in the different gestational weeks in the observation group was higher than that in the control group，with significant difference （P0.05）.The level of serum FFA and TM in the two groups gradually increased along with the increase of gestational weeks，with significant difference （P0.05）.There was a positive correlation between TM and serum FFA （r=0.6604，P0.05）. Conclusion The incidence of hypertensive disorder complicating pregnancy is associated with high FFA level and TM level，and the TM level has a positive correlation with the concentration of FFA. 　　[Key words] Free fatty acid；Thrombomodulin；Gestation period；Enzyme linked immunoassay 　　妊娠期高血压疾病是妊娠期常见的