醋酸亮丙瑞林治疗儿童中枢性性早熟临床分析.docVIP

醋酸亮丙瑞林治疗儿童中枢性性早熟临床分析 　　[摘要] 目的 探讨醋酸亮丙瑞林治疗儿童中枢性性早熟（CPP）的临床疗效。方法 收集2010年11月～2012年11月我院儿科收治的CPP患儿56例，随机分为观察组与对照组各28例，对照组予口服醋酸甲地孕酮，观察组在此基础上加用醋酸亮丙瑞林缓释剂，比较两组的临床疗效。 结果 两组治疗后的性激素水平、生长指标、子宫及卵巢容积等均获得了不同程度的改善，观察组显著优于对照组（P0.05）。 结论 醋酸亮丙瑞林用于治疗中枢性性早熟能够有效抑制垂体促性腺激素以及性激素的分泌，延缓骨龄并控制性征的异常发育，疗效显著，不良反应少，值得在临床中推广应用。 　　[关键词] 中枢性性早熟；儿童；亮丙瑞林；临床疗效 　　[中图分类号] R725.8[文献标识码] B[文章编号] 1673-9701（2014）16-0047-04 　　 　　Clinical analysis of leuprolide in treatment of children central precocious puberty 　　DING Shuxia1 WU Jing2 ZHANG Jianping1 YU Xiaomei1 　　1.Pediatric Hospital for Women and Children in Ningbo City of Zhejiang Province， Ningbo 315010, China；2.Zhejiang Province Lishui Peoples Hospital， Lishui 323000, China 　　[Abstract] Objective To evaluate the clinical efficacy of leuprolide in treatment of children central precocious puberty（CPP）. Methods Fifty-six cases of children CPP admitted to the pediatric in our hospital between November 2010 and 2012 November were collected，Children were randomLy divided into observation group and control group， 28 cases in each group，the control group received oral megestrol acetate，observation group was added with leuprolide based on the control group，the clinical efficacy of the two groups was compared. Results The hormone levels，growth indicators，uterine and ovarian volume in two groups after treatment were all awarded varying degrees of improvement，and these indicators in the observation group were significantly better than the control group（P0.05）. Conclusion Leuprolide acetate for the treatment of central precocious puberty can effectively inhibit the secretion of pituitary gonadotropins and sex hormones， bone age delay and controlling symptoms of abnormal development， it has a significant effect and fewer adverse reactions， should be promoted in clinical applications. 　　[Key words] Central precocious puberty; Child; Leuprolide; Clinical efficacy中枢性性早熟（CPP）是最为常见的一种性早熟类型，主要是因“下丘脑-垂体-性腺”系统功能提前启动引起，主要表现为青春期前即出现第二性征，例如出现腋毛、阴毛、乳房发育、体重及身高迅速增长等[1]。CPP多