IMMUNOLOGY-浙江大学个人主页.pptVIP

* * Alternative pathway It is rather different from the MBL and classical pathway. 1. no C1,C4 and C2 involved factor B and factor D involved 2. the presence of suitable activator surfaces,such as bacterial and fungal cell walls. 3. C3b: from the classical pathway; spontaneous produced C3b complement Characters of alternative pathway 1. it can recognize “self” and “non-self” 2. the amplification loop Mannan-binding lectin pathway Activators：MBL (similar to C1q, hexamer) MBL recognizes certain carbohydrates expressed on the surface of m