重组人干扰素α2b阴道泡腾胶囊治疗HPV感染Meta分析.docVIP

重组人干扰素α2b阴道泡腾胶囊治疗HPV感染Meta分析 　　[摘要] 目的 系?y评价重组人干扰素α2b阴道泡腾胶囊（辛复宁）治疗人乳头瘤病毒（HPV）感染的效果和安全性，为辛复宁治疗HPV感染提供循证医学证据。 方法 计算机检索PubMed、EMbase、Cochrane Library、CBM、Wanfang、CNKI和VIP数据库建库至2017年5月的CCT和RCT，并对全部纳入文献的参考文献进行追溯，由两位评价者根据纳入排除标准独立对文献进行筛选和评价，然后进行数据提取。运用RevMan 5.3软件进行统计分析。 结果 纳入23篇文献，共3442例患者，3个月后检测结果显示辛复宁单药治疗组对HPV的疗效优于对照组（OR = 11.67，95%CI：5.50～24.75，P 0.000 01）；6个月后检测结果显示辛复宁单药治疗组对HPV的疗效优于对照组（OR = 2.03，95%CI：1.41～2.92，P = 0.0001）；12个月后检测结果显示辛复宁单药治疗组对HPV的疗效与对照组比较差异无统计学意义（OR = 1.24，95%CI：0.85～1.81，P = 0.26）。两组均未见明显不良反应。 结论 辛复宁治疗HPV感染效果显著，安全性较好。 　　[关键词] 重组人干扰素α2b阴道泡腾胶囊；人乳头瘤病毒；感染；Meta分析 　　[中图分类号] R373.9 [文献标识码] A [文章编号] 1673-7210（2017）11（a）-0111-05 　　Recombinant Human Interferon α2b Vaginal Effervescent Capsules in the treatment of patients with HPV infection： a Meta-analysis 　　ZHANG Shudan1 LI Qi2 LI Ge3 　　1.Department of Pharmacy， Dalian Hospital of Traditional Chinese Medicine， Liaoning Province， Dalian 116013， China； 2.Department of Internal Medicine， the Third Hospital of Wafangdian， Liaoning Province， Wafangdian 116300， China； 3.Department of Oncology， Dalian Hospital of Traditional Chinese Medicine， Liaoning Province， Dalian 116013， China 　　[Abstract] Objective To review systematically the curative effect and safety of Recombinant Human Interferon α2b Vaginal Effervescent Capsules （Xinfuning） on HPV infection， and provide clinicians with an evidence base for their clinical decision making. Methods The databases of PubMed， EMbase， Cochrane Library， CBM， Wanfang， CNKI and VIP were retrieved for collecting RCT and CCT about the treatment of HPV infection with Xinfuning before May 2017， and reference lists were also searched. According to the inclusion and exclusion criteria， two reviewers screened and assessed the potential studies independently， and then the data was extracted. The data was given a Meta-analysis by using RevMan 5.3 software. Results Twenty-three study articles were included， involving 3442 patients. After 3 months， the test results showed that the