降钙素原以及C反应蛋白对老年性重症肺感染病原体鉴别意义.docVIP

降钙素原以及C反应蛋白对老年性重症肺感染病原体鉴别意义 　　[摘要] 目的 探讨血清中降钙素原（PCT）以及C-反应蛋白（CRP）在老年性重症肺感染中病原体鉴别诊断的意义。方法整群选取该院2012年1月―2015年1月间收治的49例老年重症肺感染患者为研究对象，按其病原学分为细菌感染组27例，病毒感染组12例，真菌感染组10例。分别检测其PCT以及CRP量。结果 细菌感染组血清PCT与CRP阳性率明显高于真菌感染组和病毒感染组，差异有统计学意义（P0.05）。 结论 肺部感染PCT与CRP均升高。不同感染类型其血清PCT升高幅度不同，而CRP含量差异不明显。PTC鉴别肺部感染病原体较 CRP更具优越性。 　　[关键词] 降钙素原；C-反应蛋白；病原体；老年肺炎 　　[中图分类号] R592 [文献标识码] A [文章编号] 1674-0742（2015）12（a）-0078-03 　　[Abstract] Objective To study the significance of Calcitonin original and C reactive protein in the identification of the pathogen of severe pulmonary infection in the elderly. Methods 49 cases of elderly patients with the pathogen of severe pulmonary infection treated in our department from January 2012 to January 2015 were selected as the research object and divided into bacterial infection group of 27 cases， virus infection group of 12 cases and fungal infection group of 10 cases according to their etiology， PCT and CRP of the three groups were detected respectively. Results The positive rates of PCT and CRP in the bacterial infection group were significantly higher than these in the fungal infection group and virus infection group， and the difference was statistically significant （P0.05）， and there was no statistically significance. Conclusion Pulmonary infection of PCT and CRP were elevated， ascending range of serum PCT was different in different infection types and the difference of CRP content was not obvious. PTC identification of pulmonary infection pathogen is more advantageous than CRP. 　　[Key words] Calcitonin original； C- reactive protein； Pathogen； Senile pneumonia 　　老年人抵抗力差，并且常合并有高血压、脑血管疾患、糖尿病等慢性病，容易并发肺部感染，老年人炎症反应不典型，症状表现和体征、实验室指标往往不典型，而且病程进展快、危害严重、病死率也较高[1]，因为缺乏早期诊断重度细菌感染的临床指标，以至于容易丧失最佳的治疗时机[2]。近年来，降钙素原作为用于全身细菌感染和鉴别诊断的血清标志物而被人们发现并应用于临床[3]。C-反应蛋白（C-reactive protein，CRP）是一种非特异性炎症反应因子，在各种病原体感染中均呈现一定程度的升高。该研究整群选取该院2012年1月―2015年1月间收治的49例老年重症肺感染患者为研究对象，探讨CRP和PCT检测对老年肺部感染诊断价值及鉴别肺部感染患者不同病原微生物的临床价值。现报告如下。 　　1 对象与方法 　　1.1 研究对象 　　整群选取该院收治的49例老年重症肺感染患者为研究对象，其中男3