降钙素原指导ICU危重患者抗菌治疗临床价值.docVIP

降钙素原指导ICU危重患者抗菌治疗临床价值 　　[摘要]目的 研究ICU危重感染患者检测降钙素原（PCT）对抗菌药物使用的指导价值。方法 选取2016年1～12月我院ICU病房收治的88例危重感染患者为研究对象，根据患者入院顺序分为常规组和PCT组，每组44例。常规组采用常规采用抗生素治疗，PCT组按PCT含量指导使用抗生素。观察两组患者治疗前后各指标水平、治疗情况以及预后情况等。结果 治疗前，两组患者WBC、CRP及PCT水平比较，差异无统计学意义（P0.05）；治疗后，两组患者WBC、CRP以及PCT水平比较，差异无统计学意义（P0.05）。PCT?M抗生素使用时间、ICU住院时间以及费用均少于常规组（P0.05）。PCT组生存率、死亡率分别为95.45%、4.55%，明显优于常规组的86.36%、13.64%（P0.05）。结论 PCT对ICU危重患者感染的抗菌治疗可起到较好的指导作用，明显减少抗生素的使用量和使用时间，提高生存率，值得临床推广应用。 　　[关键词]降钙素原；重症监护病房；抗菌治疗 　　[中图分类号] R446 [文献标识码] A [文章编号] 1674-4721（2017）03（c）-0037-03 　　[Abstract]Objective To investigate the guidance value of procalcitonin （PCT） in the detection of antibacterial agents usage for critically ill infected patients in ICU.Methods 88 cases of critically ill patients in ICU admitted to our hospital from January to December 2016 were selected as study object and divided into routine group and PCT group according to the order of admission with 44 patients respectively in each group，patients in the routine group were treated with antibiotics，and patients in the PCT group were treated with antibiotic by the guidance of PCT content.Each index level before and after treatment，treatment and prognosis in two groups were observed.Results There was no difference in the levels of WBC，CRP and PCT before treatment between two groups （P0.05）；after treatment，there was still no difference in WBC，CRP and PCT levels between two groups （P0.05）.The antibiotic use time，ICU hospitalization time and costs of the PCT group was less than that of the routine group （P0.05）.The survival rate and mortality rate of the PCT group was 95.45% and 4.55% respectively，which was significantly higher than 86.36% and 13.64% in the routine group （P0.05）.Conclusion PCT can play a good role in guiding the treatment of ICU infection in critically ill patients，can significantly reduce the amount of the antibiotics and time，improve the survival rate，which is worthy of clinical promotion and application. 　　[Key words]Procalcitonin；ICU；Antibacterial