顺铂序贯榄香烯联合热疗治疗恶性胸腔积液效果分析.docVIP

顺铂序贯榄香烯联合热疗治疗恶性胸腔积液效果分析 　　[摘要]目的 分析顺铂序贯榄香烯联合热疗治疗胸腔积液患者的临床效果。方法 选取2010年7月～2015年7月北京燕化医院收治并经病理证实的恶性胸腔积液患者100例，按照随机数字表法分为实验组和对照组，每组各50例。所有患者均行胸腔内中心静脉导管置管引流。实验组患者给予顺铂+榄香烯胸腔内灌注联合热疗，对照组患者仅给予顺铂+榄香烯胸腔灌注。观察比较两组患者的治疗效果及不良反应。结果 治疗后，实验组患者治疗总有效率为88%，对照组患者为64%，差异有统计学意义（P0.05）。结论 顺铂序贯榄香烯胸腔内灌注联合热疗治疗肺癌恶性胸腔积液的效果安全有效，值得在临床上推广。 　　[关键词]胸腔积液；顺铂；榄香烯；热疗；临床疗效；化疗 　　[中图分类号] R730.53 [文献标识码] A [文章编号] 1674-4721（2016）11（a）-0074-03 　　[Abstract]Objective To analyze clinical effect of Cisplatin and Elemene combined with hyperthermia in treatment of patients with pleural effusion.Methods One hundred cases with malignant pleural effusion were selected from July 2010 to July 2015 in Beijing Yanhua Hospital，and they were divided into experimental group and control group according to the random number table method，50 cases in each group.All patients underwent indwelling catheter drainage of central venous catheter in the thoracic cavity，and patients in the control group were given intrathoracic perfusion by Cisplatin and Elemene，patients in the experimental group were additionally treated hyperthermi based on the control group.The therapeutic effect and adverse reactions of patients in the two groups were compared.Results After treatment，the total efficiency in the experimental group was 88%，and the control group was 64%，the difference was statistically significant （P0.05）.Conclusion Effect of Cisplatin sequential Elemene intrapleural injection combined with hyperthermia in the treatment of malignant pleural effect is safe and effective，it is worthy of clinical application. 　　[Key words]Pleural effusion；Cisplatin；Elemene；Hyperthermia；Clinical efficacy；Chemotherapy 　　恶性胸腔积液是恶性肿瘤转移至胸膜后产生，常见于肺癌、肝癌、卵巢癌等恶性肿瘤晚期，大量胸腔积液可导致胸闷、气短、不能平卧等临床不适，预后差，生存期缩短，严重影响患者生活质量[1]。目前临床常用的治疗方法有利尿、全身化疗、胸腔穿刺引流等。由于恶性胸腔积液生长速度快，抽取后易反复发生，反复抽取胸水可造成患者白蛋白丢失、电解质紊乱等并发症，严重者甚至可导致循环衰竭从而加速死亡[2]。本研究选取北京燕化医院（以下简称“我院”）收治的100例恶性胸腔积液患者，随机分组，分别采用胸腔内序贯灌注药物方法联合热疗和单纯序贯灌注治疗癌性胸腔积液，比较治疗效果，现报道如下。 　　1资料与方法 　　1.1一般资料 　　选择2010年7月～2015年7月我院收治的100例恶性胸腔积液患