颅脑损伤患者血清及CSF内IL―1βIL―6表达与损伤程度相关性研究.docVIP

颅脑损伤患者血清及CSF内IL―1βIL―6表达与损伤程度相关性研究 　　[摘要] 目的 探讨IL-1β、IL-6 与颅脑损伤（TBI）程度的关系及临床意义。 方法 2010年1月～2012年12月我院收治的TBI患者231例，于伤后1 d、3 d、7 d、10 d检测血清及脑脊液（CSF）中 IL-1β 及 IL-6 水平。根据格拉斯哥昏迷量表评估损伤程度，将患者分为轻型组72例、中型组84例、重型组75例，比较三组IL-1β 及 IL-6 水平。伤后6个月，根据格拉斯哥预后量表评估显示，死亡28例、植物生存3例、重残25例、中残31例、恢复良好144例。比较不同预后患者IL-1β及IL-6水平。 结果 轻型组及中型组IL-1β、IL-6水平无明显差异，但两者均低于重型组（P0.05）。死亡、植物生存患者IL-1β、IL-6水平无明显差异，但两者均高于重残患者（P0.05）。死亡、植物生存及重残患者IL-1β、IL-6水平均高于中残及预后良好患者（P0.05）。 结论 血清及脑脊液中IL-1β、IL-6水平与TBI损伤程度及预后密切相关。 　　[关键词] 颅脑损伤；血清；脑脊液；炎性因子 　　[中图分类号] R651 [文献标识码] A [文章编号] 1673-9701（2015）25-0008-05 　　The relationship between IL-1β， IL-6 in serum and cerebro-spinal fluid and severity of traumatic brain injury 　　TIAN Da1 LIU Hong2 LI Huguang1 　　1.Department of Neurosurgery， Lishui People’s Hospital in Zhejiang Province， Lishui 323000， China； 2.Emergency ICU， Lishui People’s Hospital in Zhejiang Province， Lishui 323000， China 　　[Abstract] Objective To investigate the relationship of interleukin （IL）-1β and IL-6 levels of patients with the severity of traumatic brain injury（TBI） and their clinical significance. Methods A total of 231 patients with TBI admitted to our hospital from Jan 2010 to Dec 2012 were measured the levels of IL-1β and IL-6 in serum and cerebro-spinal fluid. All the patients were divided into mild injury group（72 cases），moderate injury group （84 cases），severe injury group （75 cases） according to the Glasgow coma scale， levels of IL-1β and IL-6 of the three groups were compared. They were divided into different groups according to the prognosis evaluated by Glasgow coma scale after treatment 6 months， death 28 cases， vegetable survival 3 cases， severe disability 25 cases， moderate disability 31 cases， good recovery 144 cases， IL-1β and IL-6 of patients with different prognosis were compared. Results IL-1β and IL-6 levels were significantly increased in mild injury group，moderate injury group，severe injury group compared with control group（P0.05）. IL-1β and IL-6 of the death and vegetable