高尿酸血症中ox―LDL和LDL系统与冠心病发病相关性研究.docVIP

高尿酸血症中ox―LDL和LDL系统与冠心病发病相关性研究 　　[摘要] 目的 探讨高尿酸血症中氧化修饰低密度脂蛋白（ox-LDL）和低密度脂蛋白（LDL）系统与冠心病发病的相关性。 方法 选择2014年10月～2016年10月入住新疆维吾尔自治区喀什地区第二人民医院（以下简称“我院”）的100例高尿酸血症患者作为研究对象，其中合并冠心病（CHD）患者38例（合并CHD组），未合并CHD患者62例（未合并CHD组）。另外选取同期于我院进行体检的健康者50名作为对照组。采用酶联免疫吸附测定（ELISA）法对ox-LDL进行测定，采用酶法对LDL进行测定。比较三组血ox-LDL及LDL水平，分析ox-LDL和LDL与冠心病的相关性。 结果 合并CHD组患者血ox-LDL及LDL水平均显著高于未合并CHD组及对照组，差异均有统计学意义（均P 0.05），未合并CHD组血ox-LDL及LDL水平均显著高于对照组，差异均有统计学意义（均P 0.05）。经Spearman分析，ox-LDL、LDL与冠心病发病呈正相关关系（r = 0.572、0.628，均P 0.05）。 结论 高尿酸血症中ox-LDL和LDL系统与冠心病发病呈正相关性，在实际治疗过程中，应该强化抗氧化治疗，并注意动态观察ox-LDL及LDL的水平变化。 　　[关键词] 高尿酸血症；冠心病；氧化修饰低密度脂蛋白；低密度脂蛋白；相关性 　　[中图分类号] R589 [文献标识码] A [文章编号] 1673-7210（2017）11（b）-0059-03 　　[Abstract] Objective To investigate the correlation of oxidized low density lipoprotein （ox-LDL） and low density lipoprotein （LDL） system with the attack of coronary heart disease in hyperuricemia. Methods One hundred patients with hyperuricemia treated in Kashi Prefecture Second Peoples Hospital， Xinjiang Uygur Autonomous Region （our hospital for short） from October 2014 to October 2016 were selected as research objects， among whom， there were 38 cases with coronary heart disease （CHD） （CHD group） and 62 cases without CHD （no CHD group）. 50 healthy controls examined in our hospital at the same time were selected as control group. The enzyme-linked immunosorbent assay （ELISA） was used to detect ox-LDL， enzymic method was used to detect LDL. The levels of blood ox-LDL and LDL in the three groups were compared， and the correlation of ox-LDL and LDL system with CHD was analyzed. Results The levels of blood ox-LDL and LDL in CHD group were significantly higher than those of no CHD group and control group， the differences were all statistically significant （all P 0.05）， and the levels of blood ox-LDL and LDL in no CHD group were significantly higher than those of control group， the differences were all statistically significant （all P 0.05）. By Spearman analysis， ox-LDL， LDL were positively correlated with