卤米松乳膏治疗神经性皮炎与慢性湿疹49例疗效观察.docVIP

卤米松乳膏治疗神经性皮炎与慢性湿疹49例疗效观察 　　【摘要】 目的 探索卤米松乳膏治疗神经性皮炎和慢性湿疹患者的临床疗效。方法 99例神经性皮炎和慢性湿疹患者， 动态随机化分为对照组（50例）和观察组（49例）。对照组实施丙酸氯倍他索软膏治疗， 观察组实施卤米松乳膏治疗。比较两组的治疗效果。结果 观察组患者药物起效时间（2.36±0.42）d 　　明显短于对照组（4.95±1.05）d， 刺激性症状、烧灼感、过敏性皮疹发生率（0、2.04%、0）均低于?φ兆椋?12.00%、14.00%、10.00%）， 差异均具有统计学意义（P0.05）。观察组患者治疗总有效率97.96%明显高于对照组的68.00%， 差异具有统计学意义（P0.05）。结论 卤米松乳膏在神经性皮炎和慢性湿疹患者中效果显著， 且安全性较高。 　　【关键词】 卤米松乳膏；神经性皮炎；慢性湿疹；疗效 　　DOI：10.14163/j.cnki.11-5547/r.2017.16.060 　　Observation on curative effect of halometasone cream in the treatment of neurodermatitis and chronic eczema SU Chun-zhi. Gaozhou City People’s Hospital， Gaozhou 525200， China 　　【Abstract】 Objective To explore the clinical curative effect of halometasone cream in the treatment of neurodermatitis and chronic eczema. Methods A total of 99 neurodermatitis and chronic eczema patients were dynamic randomly divided into control group （50 cases） and observation group （49 cases）. The control group received clobetasol propionate unguent for treatment， and the observation group received halometasone cream for treatment. Therapeutic effect was compared in two groups. Results The observation group had obviously shorter drug onset time as （2.36±0.42） d than （4.95±1.05） d in the control group， and lower incidence of irritation， burning sensation and allergic skin rashes （0， 2.04% and 0） than the control group （12.00%， 14.00% and 10.00%）， and their difference had statistical significance （P0.05）. The observation group had obviously higher total treatment effective rate as 97.96% than 68.00% in the control group， and the difference had statistical significance （P0.05）. Conclusion Halometasone cream shows significant effect in the treatment of neurodermatitis and chronic eczema patients with high safety. 　　【Key words】 Halometasone cream； Neurodermatitis； Chronic eczema； Curative effect 　　神经性皮炎和慢性湿疹存在相同点和不同点， 主要相同点为：均存在瘙痒、皮肤破损等临床表现， 且属于顽固性慢性皮肤病[1]。不同点在于疾病的特征：神经性皮炎呈现为黄褐色， 皮肤处可见绿豆状丘疹， 形状多为三角形和圆形， 边界清晰， 呈密集性分布；慢性湿疹呈现为浅灰色， 皮肤处可见增厚现象， 表面覆盖少数鳞屑， 存在强烈瘙痒感[2