甲氨喋呤与米非司酮联合保守治疗异位妊娠疗效观察.docVIP

甲氨喋呤与米非司酮联合保守治疗异位妊娠疗效观察 　　[摘要] 目的 探讨甲氨蝶呤联合米非司酮治疗异位妊娠的疗效。方法 收集我院2008年9月～2010年3月未破裂输卵管妊娠患者62例，随机分为观察组和对照组各31例。观察组给予甲氨蝶呤和米非司酮联合治疗，对照组给予甲氨蝶呤治疗。观察两组治愈率、治疗前后盆腔包块大小、血β-HCG变化及不良反应发生情况。结果 观察组的治愈率明显高于对照组，两者比较差异有统计学意义（P＜0.05）；观察组和对照组治疗后血β-HCG均较治疗前显著降低，但观察组降低幅度大于对照组（P＜0.05）；盆腔包块大小治疗后两组无显著性差异（P＞0.05）；两组患者不良反应发生率差异无统计学意义。结论 甲氨蝶呤联合米非司酮保守治疗异位妊娠效果较好，值得临床推广。 　　[关键词] 甲氨蝶呤；米非司酮；异位妊娠；血β-HCG 　　[中图分类号] R714.22 [文献标识码] B [文章编号] 1673-9701（2011）22-66-02 　　 　　Methotrexate Combined with Mifepristone in Treatment of Ectopic Pregnancy：An Clinical Observation 　　XIA Lijuan 　　MCH Hospital of Lanxi City in Zhejiang Province， Lanxi 321100，China 　　 　　[Abstract] Objective To explore the effect of methotrexate combined with mifepristone on ectopic pregnancy. Methods 62 cases of non-reptured tubal preghancy were select from Sep 2008 to Mar 2010 in our hospital， they were randomly divided into control group and observation group， each having 31 cases. Observation group was treated with methotrexate and mifepristone，but the control group was treated with methotrexate only，the cure rate，β-HCG of blood，the size of the adnexal mass of before and after treatment and adverse effect were observed after treatment. Results The cure rate of observation group was higher than that of control group，there was a significant difference（P＜0.05）；β-HCG of blood in two group after treatment were much lower than before treatment，the reduction of the treatment group was larger than control group（P＜0.05）； There were no significant difference in the adnexal mass and the rate of adverse effect between two groups after treatment（P＞0.05）. Conclusion The effect of methotrexate combined with mifepristone on ectopic pregnancy is good，this method is worthy of application. 　　[Key words] Methotrexate；Mifepristone；Ectopic pregnancy；β-HCG of blood 　　 　　异位妊娠是孕卵在子宫外着床发育的异常妊娠，是一种妇产科临床常见的急腹症，严重威胁着孕产妇的身体健康及生命安全，是引起临床上孕产妇死亡的主要原因之一。近年来其发病率呈不断上升趋势，据调查，占所有妊娠的1%左右[1，2]。临床上该病传统的治疗方法是手术治疗，即开腹行输卵管切除术，这种方法虽然疗效较好，但是对有生育要求的女性来说，并不是理想的选择。近几年，随