分析研究HBV与HCV重叠感染患者生化免疫指标变化及临床意义.docVIP

分析研究HBV与HCV重叠感染患者生化免疫指标变化及临床意义 　　【摘要】 目的 探?乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）单纯及重叠感染患者白细胞介素-6（IL-6）以及γ-干扰素（IFN-γ）水平状况。方法 126例肝炎病毒患者， 其中42例HBV单纯感染者作为HBV组， 42例HCV单纯感染者作为HCV组， 42例HBV和HCV重叠感染者作为HBV与HCV重叠感染组；选取同期42例健康体检者作为普通组。四组均进行IL-6、IFN-γ检测， 并进行组间比较。结果 普通组IL-6水平为（28.20±8.30）ng/L、IFN-γ水平为（20.50±5.36）ng/L， HBV组IL-6水平为（53.45±25.40）ng/L、IFN-γ水平为（45.42±20.40）ng/L， HCV组IL-6水平为（56.42±25.20）ng/L、IFN-γ水平为（50.45±20.25）ng/L， HBV与HCV重叠感染组IL-6水平为（86.55±40.30）ng/L、IFN-γ水平为（50.25±25.49）ng/L， HBV组、HCV组、HBV与HCV重叠感染组IL-6、IFN-γ水平均显著高于普通组， 差异均具有统计学意义（P0.05）。结论 HBV与HCV重叠感染患者病情的发展与IL-6和IFN-γ水平密切相关， IL-6可作为判断患者病情的一项金指标。 　　【关键词】 乙型肝炎病毒；丙型肝炎病毒；重叠感染；生化免疫指标 　　DOI：10.14163/j.cnki.11-5547/r.2017.35.012 　　Analysis and study of biochemical immune index changes and clinical significance in patients with superinfection of HBV and HCV GAO Zhi-fang， CHEN Jian-hua， PAN Yan-fang， et al. Guangning County Traditional Chinese Medicine Hospital， Zhaoqing 526300， China 　　【Abstract】 Objective To discuss the level of interleukin-6 （IL-6） and interferon-γ （IFN-γ） in patients with simple and overlapping infections of hepatitis B virus （HBV） and hepatitis C virus （HCV）. Methods 126 cases of hepatitis B patients， including 42 cases of simple HBV infection as HBV group， 42 cases of simple HCV infection as HCV group， 42 cases of superinfection of HBV and HCV as HBV and HCV superinfection group. 42 healthy subjects were selected as normal group. All four groups were tested for IL-6， IFN-γ， and compared between groups. Results The normal group had IL-6 level as （28.20±8.30） ng/L， IFN-γ level as （20.50±5.36） ng/L， HBV group had IL-6 level as （53.45±25.40） ng/L， IFN-γ level as （45.42±20.40） ng/L， HCV group had IL-6 level as （56.42±25.20） ng/L， IFN-γ level as （50.45±20.25） ng/L， and HBV and HCV superinfection group had IL-6 as （86.55±40.30） ng/L， IFN-γ level as （50.25±25.49） ng/L. HBV group， HCV group， HBV and HCV superinfection group had obviously higher IL-6 and IFN-γ level than normal group， and their difference was statist