阿奇霉素、丙种球蛋白、利福平联合用药治疗儿童难治性肺炎支原体肺炎的效果观察.docVIP

阿奇霉素、丙种球蛋白、利福平联合用药治疗儿童难治性肺炎支原体肺炎的效果观察 　　[摘要]目的 探讨阿奇霉素、丙种球蛋白、利福平联合用药对难治性肺炎支原体肺炎的疗效。方法 选取2012年3月～2016年3月在我院诊断为难治性肺炎支原体肺炎的患儿93例，采用随机数字表法将其分为对照组47例与观察组46例。对照组采用阿奇霉素治疗，治疗组采用阿奇霉素、丙种球蛋白、利福平治疗。将两组间的疗效、症状改善时间进行比较。结果 治疗3 d后，观察组患者的有效率显著优于对照组，差异有统计学意义（P0.05）；观察组患者症状改善时间显著短于对照组，差异有统计学意义（P0.05）。结论 阿奇霉素、丙种球蛋白、利福平联合用药治疗儿童难治性肺炎支原体肺炎，具有较好的退热和缓解咳嗽的作用，有较高的实用价值。 　　[关键词]难治性肺炎；支原体肺炎；阿奇霉素；丙种球蛋白；利福平 　　[中图分类号] R725 [文献标识码] A [文章编号] 1674-4721（2018）2（a）-0144-03 　　[Abstract]Objective To investigate the effect of Azithromycine Combined with Gamma Globulin and Rifampicin in the treatment of children with Refractory Mycoplasma pneumoniae pneumonia.Methods From March 2012 to March 2016，93 children diagnosed as refractory Mycoplasma pneumoniae pneumonia in our hospital were randomly divided into control group （47 cases） and observation group （46 cases）.The control group was treated with azithromycin，while the treatment group was treated with Azithromycin，Gamma globulin and Rifampicin.The curative effect and symptom improvement time were compared between the two groups.Results After 3 days of treatment，the effective rate of the observation group was significantly better than that of the control group，the difference was statistically significant （P0.05）；The improvement time of symptoms in the observation group was significantly shorter than that in the control group （P0.05）.Conclusion Azithromycine combined with Gamma Globulin and Rifampicin in the treatment of children with refractory Mycoplasma pneumoniae pneumonia has better clinical efficiency，with can effectively reduce the symptoms improved time with a high clinical value. 　　[Key words]Refractory pneumonia，Mycoplasma pneumonia；Azithromycine；Azithromycine；Gamma Globulin；Rifampicin 　　肺炎支原?w感染是儿科常见感染性疾病，好发于各年龄组儿童，以学龄儿童最常见。肺炎支原体肺炎占我国社区获得性肺炎的10%～40%，肺炎支原体肺炎临床表现不一，绝大多数肺炎支原体肺炎患儿症状较轻。但是有一部分患儿病情重，大环内酯类抗生素治疗效过差，表现为持续高热、肺部影像学加重等，称为难治性肺炎支原体肺炎。近年来，难治性肺炎支原体肺炎比较常见[1]，肺外并发症日益增多。国内报道难治性肺炎支原难治性肺炎支原体肺炎体肺炎肺外脏器累及可达45.7%[2]。国外报道肺外脏器累及达25%～45%[3]。笔者于2012年3月～201